4n5u

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==Crystal structure of the 4th FN3 domain of human Protein Tyrosine phosphatase, receptor type F [PSI-NYSGRC-006240]==
==Crystal structure of the 4th FN3 domain of human Protein Tyrosine phosphatase, receptor type F [PSI-NYSGRC-006240]==
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<StructureSection load='4n5u' size='340' side='right' caption='[[4n5u]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
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<StructureSection load='4n5u' size='340' side='right'caption='[[4n5u]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4n5u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N5U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4n5u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N5U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LAR, PTPRF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5u OCA], [https://pdbe.org/4n5u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n5u RCSB], [https://www.ebi.ac.uk/pdbsum/4n5u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5u ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n5u OCA], [http://pdbe.org/4n5u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n5u RCSB], [http://www.ebi.ac.uk/pdbsum/4n5u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n5u ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTPRF_HUMAN PTPRF_HUMAN]] Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).<ref>PMID:10338209</ref> The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.<ref>PMID:10338209</ref>
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[https://www.uniprot.org/uniprot/PTPRF_HUMAN PTPRF_HUMAN] Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).<ref>PMID:10338209</ref> The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.<ref>PMID:10338209</ref>
==See Also==
==See Also==
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*[[Tyrosine phosphatase|Tyrosine phosphatase]]
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*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Large Structures]]
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[[Category: Almo, S C]]
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[[Category: Almo SC]]
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[[Category: Attonito, J]]
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[[Category: Attonito J]]
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[[Category: Banu, R]]
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[[Category: Banu R]]
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[[Category: Bhosle, R]]
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[[Category: Bhosle R]]
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[[Category: Calarese, D A]]
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[[Category: Calarese DA]]
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[[Category: Casadevall, A]]
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[[Category: Casadevall A]]
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[[Category: Celikgil, A]]
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[[Category: Celikgil A]]
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[[Category: Chamala, S]]
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[[Category: Chamala S]]
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[[Category: Chan, M K]]
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[[Category: Chan MK]]
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[[Category: Chowdhury, S]]
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[[Category: Chowdhury S]]
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[[Category: Fiser, A]]
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[[Category: Fiser A]]
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[[Category: Garforth, S J]]
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[[Category: Garforth SJ]]
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[[Category: Glenn, A S]]
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[[Category: Glenn AS]]
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[[Category: Hillerich, B]]
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[[Category: Hillerich B]]
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[[Category: IFN, Atoms-to-Animals:.The Immune Function Network]]
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[[Category: Khafizov K]]
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[[Category: Khafizov, K]]
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[[Category: Kumar PR]]
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[[Category: Kumar, P R]]
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[[Category: Love JD]]
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[[Category: Love, J D]]
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[[Category: Patel H]]
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[[Category: Structural genomic]]
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[[Category: Patel R]]
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[[Category: Patel, H]]
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[[Category: Seidel RD]]
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[[Category: Patel, R]]
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[[Category: Smith B]]
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[[Category: Seidel, R D]]
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[[Category: Stead M]]
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[[Category: Smith, B]]
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[[Category: Toro R]]
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[[Category: Stead, M]]
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[[Category: Toro, R]]
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[[Category: Hydrolase]]
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[[Category: Internal fn3 domain]]
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[[Category: Psi-biology]]
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Revision as of 10:37, 28 December 2022

Crystal structure of the 4th FN3 domain of human Protein Tyrosine phosphatase, receptor type F [PSI-NYSGRC-006240]

PDB ID 4n5u

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