1mx5

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[[Image:1mx5.gif|left|200px]]
[[Image:1mx5.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1mx5 |SIZE=350|CAPTION= <scene name='initialview01'>1mx5</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1mx5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HTQ:HOMOTROPINE'>HTQ</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxylesterase Carboxylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.1 3.1.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1mx5| PDB=1mx5 | SCENE= }}
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|RELATEDENTRY=[[1mx1|1MX1]], [[1mx9|1MX9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mx5 OCA], [http://www.ebi.ac.uk/pdbsum/1mx5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mx5 RCSB]</span>
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}}
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'''Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue'''
'''Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue'''
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[[Category: Redinbo, M R.]]
[[Category: Redinbo, M R.]]
[[Category: Xue, Y.]]
[[Category: Xue, Y.]]
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[[Category: cocaine]]
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[[Category: Cocaine]]
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[[Category: esterase]]
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[[Category: Esterase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:49:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:22:22 2008''
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Revision as of 22:49, 2 May 2008

Image:1mx5.gif


PDB ID 1mx5

Drag the structure with the mouse to rotate
1mx5, resolution 2.80Å ()
Ligands: , , , ,
Activity: Carboxylesterase, with EC number 3.1.1.1
Related: 1mx1, 1mx9
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Human Liver Carboxylesterase in complexed with homatropine, a cocaine analogue


Overview

We present the first crystal structures of a human protein bound to analogs of cocaine and heroin. Human carboxylesterase 1 (hCE1) is a broad-spectrum bioscavenger that catalyzes the hydrolysis of heroin and cocaine, and the detoxification of organophosphate chemical weapons, such as sarin, soman and tabun. Crystal structures of the hCE1 glycoprotein in complex with the cocaine analog homatropine and the heroin analog naloxone provide explicit details about narcotic metabolism in humans. The hCE1 active site contains both specific and promiscuous compartments, which enable the enzyme to act on structurally distinct chemicals. A selective surface ligand-binding site regulates the trimer-hexamer equilibrium of hCE1 and allows each hCE1 monomer to bind two narcotic molecules simultaneously. The bioscavenger properties of hCE1 can likely be used to treat both narcotic overdose and chemical weapon exposure.

About this Structure

1MX5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme., Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR, Nat Struct Biol. 2003 May;10(5):349-56. PMID:12679808 Page seeded by OCA on Sat May 3 01:49:35 2008

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OCA

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