4e74

<StructureSection load='4e74' size='340' side='right' caption='[[4e74]], [[Resolution|resolution]] 1.58&Aring;' scene=''>

<table><tr><td colspan='2'>[[4e74]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E74 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLXNA4, KIAA1550, PLXNA4A, PLXNA4B, UNQ2820/PRO34003 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e74 OCA], [http://pdbe.org/4e74 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4e74 RCSB], [http://www.ebi.ac.uk/pdbsum/4e74 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4e74 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/PLXA4_HUMAN PLXA4_HUMAN]] Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).

[[Category: Human]]

[[Category: Arrowsmith, C H]]

[[Category: Bountra, C]]

[[Category: Dong, A]]

[[Category: Edwards, A M]]

[[Category: Guan, X]]

[[Category: Park, H]]

[[Category: Structural genomic]]

[[Category: Tempel, W]]

[[Category: Tong, Y]]

[[Category: Wang, H]]

[[Category: Weigelt, J]]

[[Category: Signaling protein]]