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2y3v

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Revision as of 07:33, 17 January 2018

N-terminal head domain of Danio rerio SAS-6

Structural highlights

2y3v is a 4 chain structure with sequence from Brachidanio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	2y3w
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SAS6_DANRE] Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells.^[1]

Publication Abstract from PubMed

Centrioles are cylindrical, nine-fold symmetrical structures with peripheral triplet microtubules strictly required to template cilia and flagella. The highly conserved protein SAS-6 constitutes the center of the cartwheel assembly that scaffolds centrioles early in their biogenesis. We determined the x-ray structure of the N-terminal domain of SAS-6 from zebrafish and show that recombinant SAS-6 self-associates in vitro into assemblies that resemble cartwheel centers. Point mutations are consistent with the notion that centriole formation in vivo depends on the interactions that define the self-assemblies observed here. Thus, these interactions are likely essential to the structural organization of cartwheel centers.

Structures of SAS-6 Suggest Its Organization in Centrioles.,van Breugel M, Hirono M, Andreeva A, Yanagisawa HA, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B Science. 2011 Jan 27. PMID:21273447^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ van Breugel M, Hirono M, Andreeva A, Yanagisawa HA, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B. Structures of SAS-6 Suggest Its Organization in Centrioles. Science. 2011 Jan 27. PMID:21273447 doi:10.1126/science.1199325
↑ van Breugel M, Hirono M, Andreeva A, Yanagisawa HA, Yamaguchi S, Nakazawa Y, Morgner N, Petrovich M, Ebong IO, Robinson CV, Johnson CM, Veprintsev D, Zuber B. Structures of SAS-6 Suggest Its Organization in Centrioles. Science. 2011 Jan 27. PMID:21273447 doi:10.1126/science.1199325

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2y3v"

@@ Line 1: / Line 1: @@
-==N-TERMINAL HEAD DOMAIN OF DANIO RERIO SAS-6==
+==N-terminal head domain of Danio rerio SAS-6==
 <StructureSection load='2y3v' size='340' side='right' caption='[[2y3v]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
 == Structural highlights ==
@@ Line 23: / Line 23: @@
 </StructureSection>
 [[Category: Brachidanio rerio]]
-[[Category: Breugel, M Van]]
+[[Category: Breugel, M van]]
 [[Category: Basal body]]
 [[Category: Cartwheel]]

2y3v

From Proteopedia

Revision as of 07:33, 17 January 2018

N-terminal head domain of Danio rerio SAS-6

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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