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3v6a

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==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==
==Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules==
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<StructureSection load='3v6a' size='340' side='right' caption='[[3v6a]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='3v6a' size='340' side='right'caption='[[3v6a]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3v6a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V6A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3v6a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6A FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u0r|3u0r]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u0r|3u0r]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">API5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">API5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6a OCA], [http://pdbe.org/3v6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3v6a RCSB], [http://www.ebi.ac.uk/pdbsum/3v6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6a OCA], [https://pdbe.org/3v6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6a RCSB], [https://www.ebi.ac.uk/pdbsum/3v6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
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[[https://www.uniprot.org/uniprot/API5_HUMAN API5_HUMAN]] Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.<ref>PMID:10780674</ref> <ref>PMID:17112319</ref> <ref>PMID:19387494</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Han, B G]]
[[Category: Han, B G]]
[[Category: Lee, B I]]
[[Category: Lee, B I]]

Revision as of 08:34, 20 July 2022

Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules

PDB ID 3v6a

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