3sn5
From Proteopedia
(Difference between revisions)
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==Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one== | ==Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one== | ||
| - | <StructureSection load='3sn5' size='340' side='right' caption='[[3sn5]], [[Resolution|resolution]] 2.75Å' scene=''> | + | <StructureSection load='3sn5' size='340' side='right'caption='[[3sn5]], [[Resolution|resolution]] 2.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3sn5]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3sn5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SN5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K2B:(8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE'>K2B</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K2B:(8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE'>K2B</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP7A1, CYP7 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP7A1, CYP7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cholesterol_7-alpha-monooxygenase Cholesterol 7-alpha-monooxygenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.17 1.14.13.17] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sn5 OCA], [https://pdbe.org/3sn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sn5 RCSB], [https://www.ebi.ac.uk/pdbsum/3sn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sn5 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CP7A1_HUMAN CP7A1_HUMAN]] Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.<ref>PMID:19965590</ref> |
==See Also== | ==See Also== | ||
| - | *[[Cytochrome P450|Cytochrome P450]] | + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Cholesterol 7-alpha-monooxygenase]] | [[Category: Cholesterol 7-alpha-monooxygenase]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 08:02, 29 June 2022
Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one
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Categories: Cholesterol 7-alpha-monooxygenase | Human | Large Structures | Arrowsmith, C H | Bountra, C | Edwards, A M | MacKenzie, F | Park, H | Structural genomic | Strushkevich, N | Tempel, W | Weigelt, J | Wernimont, A K | Bile acid biosynthesis | Cholest-4-en-3-one | Cholesterol 7-alpha hydroxylase | Cyp7a1 | Cytochrome p450 | Oxidoreductase | Sgc
