4k8u
From Proteopedia
(Difference between revisions)
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==Crystal structure of TRAF4 TRAF domain== | ==Crystal structure of TRAF4 TRAF domain== | ||
| - | <StructureSection load='4k8u' size='340' side='right' caption='[[4k8u]], [[Resolution|resolution]] 2.30Å' scene=''> | + | <StructureSection load='4k8u' size='340' side='right'caption='[[4k8u]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K8U FirstGlance]. <br> | <table><tr><td colspan='2'>[[4k8u]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K8U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K8U FirstGlance]. <br> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref> | [[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The TNF receptor-associated factor (TRAF) proteins are structurally similar scaffold proteins that mediate between members of the TNF receptor (TNFR) family and downstream effector molecules such as kinases in the immune signalling pathway. Seven TRAFs have been identified, including TRAF4, which is a unique member that participates in many ontogenic processes, including nerve-system development. TRAFs commonly contain the TRAF domain, which mediates interaction with target receptors and effectors. As a first step towards elucidating the molecular mechanisms of the TRAF4-mediated signalling pathway, the first crystal structure of the human TRAF4 TRAF domain with a coiled-coil domain is reported at 2.3 A resolution. | ||
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| + | Structure of the TRAF4 TRAF domain with a coiled-coil domain and its implications for the TRAF4 signalling pathway.,Yoon JH, Cho YJ, Park HH Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):2-10. doi:, 10.1107/S139900471302333X. Epub 2013 Dec 24. PMID:24419373<ref>PMID:24419373</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4k8u" style="background-color:#fffaf0;"></div> | ||
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| + | ==See Also== | ||
| + | *[[TNF receptor-associated factor|TNF receptor-associated factor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Park, H H]] | [[Category: Park, H H]] | ||
[[Category: Yoon, J H]] | [[Category: Yoon, J H]] | ||
Revision as of 08:37, 1 January 2020
Crystal structure of TRAF4 TRAF domain
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