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4efh

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==Acanthamoeba Actin complex with Spir domain D==
==Acanthamoeba Actin complex with Spir domain D==
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<StructureSection load='4efh' size='340' side='right' caption='[[4efh]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
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<StructureSection load='4efh' size='340' side='right'caption='[[4efh]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4efh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii] and [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4EFH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4efh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii] and [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EFH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ue5|3ue5]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4efh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efh OCA], [https://pdbe.org/4efh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4efh RCSB], [https://www.ebi.ac.uk/pdbsum/4efh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4efh ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">spir, p150-Spir, CG10076 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4efh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4efh OCA], [http://pdbe.org/4efh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4efh RCSB], [http://www.ebi.ac.uk/pdbsum/4efh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4efh ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACT1_ACACA ACT1_ACACA]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[http://www.uniprot.org/uniprot/SPIR_DROME SPIR_DROME]] Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Promotes dissociation of capu from the barbed end of actin filaments. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for localization of determinants within the developing oocyte to the posterior pole and to the dorsal anterior corner. Links Rho family signaling and Jnk function to the actin cytoskeleton.<ref>PMID:10556052</ref> <ref>PMID:10744979</ref> <ref>PMID:15674283</ref> <ref>PMID:20538977</ref> <ref>PMID:21730168</ref>
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[[https://www.uniprot.org/uniprot/ACT1_ACACA ACT1_ACACA]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Actin|Actin]]
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*[[Actin 3D structures|Actin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Acanthamoeba castellanii]]
[[Category: Acanthamoeba castellanii]]
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
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[[Category: Chen, C]]
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[[Category: Large Structures]]
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[[Category: Phillips, M]]
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[[Category: Chen C]]
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[[Category: Quinlan, M E]]
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[[Category: Phillips M]]
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[[Category: Sawaya, M R]]
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[[Category: Quinlan ME]]
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[[Category: Contractile protein]]
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[[Category: Sawaya MR]]
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[[Category: Contractile protein-transport protein complex]]
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[[Category: Cytoskeleton]]
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Revision as of 07:08, 28 September 2022

Acanthamoeba Actin complex with Spir domain D

PDB ID 4efh

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