1n1h

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[[Image:1n1h.gif|left|200px]]
[[Image:1n1h.gif|left|200px]]
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{{Structure
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|PDB= 1n1h |SIZE=350|CAPTION= <scene name='initialview01'>1n1h</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1n1h", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CH1:3&#39;-DEOXY-CYTIDINE-5&#39;-TRIPHOSPHATE'>CH1</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=G7M:N7-METHYL-GUANOSINE-5&#39;-MONOPHOSPHATE'>G7M</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GH3:3&#39;-DEOXY-GUANOSINE-5&#39;-TRIPHOSPHATE'>GH3</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10886 Mammalian orthoreovirus 3])
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|DOMAIN=
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{{STRUCTURE_1n1h| PDB=1n1h | SCENE= }}
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|RELATEDENTRY=[[1muk|1MUK]], [[1mwh|1MWH]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1h OCA], [http://www.ebi.ac.uk/pdbsum/1n1h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n1h RCSB]</span>
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'''Initiation complex of polymerase lambda3 from reovirus'''
'''Initiation complex of polymerase lambda3 from reovirus'''
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[[Category: Nibert, M L.]]
[[Category: Nibert, M L.]]
[[Category: Tao, Y.]]
[[Category: Tao, Y.]]
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[[Category: initiation complex]]
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[[Category: Initiation complex]]
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[[Category: polymerase]]
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[[Category: Polymerase]]
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[[Category: right hand configuration]]
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[[Category: Right hand configuration]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:58:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:23:59 2008''
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Revision as of 22:58, 2 May 2008

Image:1n1h.gif

Template:STRUCTURE 1n1h

Initiation complex of polymerase lambda3 from reovirus


Overview

The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.

About this Structure

1N1H is a Single protein structure of sequence from Mammalian orthoreovirus 3. Full crystallographic information is available from OCA.

Reference

RNA synthesis in a cage--structural studies of reovirus polymerase lambda3., Tao Y, Farsetta DL, Nibert ML, Harrison SC, Cell. 2002 Nov 27;111(5):733-45. PMID:12464184 Page seeded by OCA on Sat May 3 01:58:22 2008

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