1n1j
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1n1j.jpg|left|200px]] | [[Image:1n1j.jpg|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1n1j", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | | | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | + | --> | |
| - | + | {{STRUCTURE_1n1j| PDB=1n1j | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''Crystal structure of the NF-YB/NF-YC histone pair''' | '''Crystal structure of the NF-YB/NF-YC histone pair''' | ||
| Line 29: | Line 26: | ||
[[Category: Moras, D.]] | [[Category: Moras, D.]] | ||
[[Category: Romier, C.]] | [[Category: Romier, C.]] | ||
| - | [[Category: | + | [[Category: Histone-like pair]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:58:28 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 22:58, 2 May 2008
Crystal structure of the NF-YB/NF-YC histone pair
Overview
The heterotrimeric transcription factor NF-Y recognizes with high specificity and affinity the CCAAT regulatory element that is widely represented in promoters and enhancer regions. The CCAAT box acts in concert with neighboring elements, and its bending by NF-Y is thought to be a major mechanism required for transcription activation. We have solved the structure of the NF-YC/NF-YB subcomplex of NF-Y, which shows that the core domains of both proteins interact through histone fold motifs. This histone-like pair is closely related to the H2A/H2B and NC2alpha/NC2beta families, with features that are both common to this class of proteins and unique to NF-Y. The structure together with the modeling of the nonspecific interaction of NF-YC/NF-YB with DNA and the full NF-Y/CCAAT box complex highlight important structural features that account for different and possibly similar biological functions of the transcriptional regulators NF-Y and NC2. In particular, it emphasizes the role of the newly described alphaC helix of NF-YC, which is both important for NF-Y trimerization and a target for regulatory proteins, such as MYC and p53.
About this Structure
1N1J is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y., Romier C, Cocchiarella F, Mantovani R, Moras D, J Biol Chem. 2003 Jan 10;278(2):1336-45. Epub 2002 Oct 24. PMID:12401788 Page seeded by OCA on Sat May 3 01:58:28 2008
