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4npl
From Proteopedia
(Difference between revisions)
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==Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate== | ==Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate== | ||
| - | <StructureSection load='4npl' size='340' side='right' caption='[[4npl]], [[Resolution|resolution]] 1.65Å' scene=''> | + | <StructureSection load='4npl' size='340' side='right'caption='[[4npl]], [[Resolution|resolution]] 1.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4npl]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4npl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPL FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4npl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npl OCA], [https://pdbe.org/4npl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npl RCSB], [https://www.ebi.ac.uk/pdbsum/4npl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npl ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Dioxygenase|Dioxygenase]] | + | *[[Dioxygenase 3D structures|Dioxygenase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Danio rerio]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chen W]] |
| - | [[Category: | + | [[Category: He C]] |
| - | [[Category: | + | [[Category: Zhang L]] |
Revision as of 08:40, 11 January 2023
Crystal structure of Zebrafish ALKBH5 in complex with alpha-ketoglutarate
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Categories: Danio rerio | Large Structures | Chen W | He C | Zhang L
