1n26

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[[Image:1n26.gif|left|200px]]
[[Image:1n26.gif|left|200px]]
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{{Structure
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|PDB= 1n26 |SIZE=350|CAPTION= <scene name='initialview01'>1n26</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1n26", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|ACTIVITY=
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|GENE= IL6R ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1n26| PDB=1n26 | SCENE= }}
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|RELATEDENTRY=[[1il6|1IL6]], [[1i1r|1I1R]], [[1n2q|1N2Q]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n26 OCA], [http://www.ebi.ac.uk/pdbsum/1n26 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n26 RCSB]</span>
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'''Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain'''
'''Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain'''
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[[Category: Simpson, R J.]]
[[Category: Simpson, R J.]]
[[Category: Varghese, J N.]]
[[Category: Varghese, J N.]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: immunoglobulin domain]]
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[[Category: Immunoglobulin domain]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:59:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:24:18 2008''
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Revision as of 22:59, 2 May 2008

Image:1n26.gif

Template:STRUCTURE 1n26

Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain


Overview

Dysregulated production of IL-6 and its receptor (IL-6R) are implicated in the pathogenesis of multiple myeloma, autoimmune diseases and prostate cancer. The IL-6R complex comprises two molecules each of IL-6, IL-6R, and the signaling molecule, gp130. Here, we report the x-ray structure (2.4 A) of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain (D(1)) is disulfide-bonded to domain D(2), and domains D(2) and D(3), the cytokine-binding domain, are structurally similar to known cytokine-binding domains. The head-to-tail packing of two closely associated IL-6R molecules observed in the crystal may be representative of the configuration of the physiological dimer of IL-6R and provides new insight into the architecture of the IL-6R complex.

About this Structure

1N26 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain., Varghese JN, Moritz RL, Lou MZ, Van Donkelaar A, Ji H, Ivancic N, Branson KM, Hall NE, Simpson RJ, Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15959-64. Epub 2002 Dec 2. PMID:12461182 Page seeded by OCA on Sat May 3 01:59:44 2008

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