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1n2d
From Proteopedia
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[[Image:1n2d.gif|left|200px]] | [[Image:1n2d.gif|left|200px]] | ||
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'''Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin''' | '''Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin''' | ||
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[[Category: Terrak, M.]] | [[Category: Terrak, M.]] | ||
[[Category: Wu, G.]] | [[Category: Wu, G.]] | ||
| - | [[Category: | + | [[Category: Iq motif]] |
| - | [[Category: | + | [[Category: Myosin light chain]] |
| - | [[Category: | + | [[Category: Protein-peptide complex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:00:16 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 23:00, 2 May 2008
Ternary complex of MLC1P bound to IQ2 and IQ3 of Myo2p, a class V myosin
Overview
Mlc1p is a calmodulin-like protein from the budding yeast Saccharomyces cerevisiae, where it has been identified as a subunit of a class V myosin, Myo2p, and a binding partner of an IQGAP-like protein, Iqg1p. Through its interactions with these two proteins, Mlc1p plays a role in polarized growth and cytokinesis. Mlc1p has been crystallized in complexes with four different IQ target motifs from the neck region of Myo2p: IQ2, IQ3, IQ4 and IQ2-IQ3 (referred to as IQ2,3). Electron-density maps for two of the complexes (Mlc1p-IQ4 and Mlc1p-IQ2,3) were obtained from multiple anomalous dispersion (MAD) experiments based on selenomethionine derivatives. The other two structures (Mlc1p-IQ2 and Mlc1p-IQ3) were determined by molecular replacement using the partially refined structure of Mlc1p-IQ2,3 as a search model.
About this Structure
1N2D is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V., Terrak M, Otterbein LR, Wu G, Palecanda LA, Lu RC, Dominguez R, Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1882-5. Epub, 2002 Sep 28. PMID:12351846 Page seeded by OCA on Sat May 3 02:00:16 2008
