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4m49

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==Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18==
==Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18==
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<StructureSection load='4m49' size='340' side='right' caption='[[4m49]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='4m49' size='340' side='right'caption='[[4m49]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m49]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M49 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4m49]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M49 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=22Y:3-(5-AMINO-6-{[(1R)-1-PHENYLETHYL]AMINO}PYRAZIN-2-YL)-4-CHLOROBENZOIC+ACID'>22Y</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=22Y:3-(5-AMINO-6-{[(1R)-1-PHENYLETHYL]AMINO}PYRAZIN-2-YL)-4-CHLOROBENZOIC+ACID'>22Y</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jnk|4jnk]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m49 OCA], [https://pdbe.org/4m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m49 RCSB], [https://www.ebi.ac.uk/pdbsum/4m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m49 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LDHA, PIG19 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m49 OCA], [http://pdbe.org/4m49 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m49 RCSB], [http://www.ebi.ac.uk/pdbsum/4m49 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m49 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[http://omim.org/entry/612933 612933]]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
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[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN] Defects in LDHA are the cause of glycogen storage disease type 11 (GSD11) [MIM:[https://omim.org/entry/612933 612933]. A metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.<ref>PMID:2334430</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/LDHA_HUMAN LDHA_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Lactate Dehydrogenase|Lactate Dehydrogenase]]
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*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: L-lactate dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Eigenbrot, C]]
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[[Category: Eigenbrot C]]
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[[Category: Ultsch, M]]
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[[Category: Ultsch M]]
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[[Category: Dehydrogenase/reductase]]
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[[Category: Nicotinamide adenine dinucleotide nadh]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Revision as of 10:54, 21 December 2022

Lactate Dehydrogenase A in complex with a substituted pyrazine inhibitor compound 18

PDB ID 4m49

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