1n3n
From Proteopedia
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'''Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db''' | '''Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db''' | ||
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[[Category: Pluckthun, A.]] | [[Category: Pluckthun, A.]] | ||
[[Category: Tissot, A C.]] | [[Category: Tissot, A C.]] | ||
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Revision as of 23:02, 2 May 2008
Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db
Overview
The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock protein (hsp) 60 is recognized by the murine T-cell receptor UZ-3-4 in complex with the murine class I major histocompatibility complex molecule H-2D(b). This T-cell receptor cross-reacts with the H-2D(b)-bound non-homologous decameric peptide KDIGNIISDA from the murine hsp60, but does not recognize the nonameric mycobacterial peptide SALQNAASI. Cross-recognition of the KDIGNIISDA/H-2D(b) complex induces autoimmune pathology in immunodeficient mice. We solved the X-ray crystal structure of the SALQNAASIA/H-2D(b) complex at 3.0 A resolution, and we modelled the KDIGNIISDA and SALQNAASI peptides in the H-2D(b) binding site. The structural analysis of the H-2D(b)-bound hsp60 epitopes offers insight into T-cell receptor cross-reactivity.
About this Structure
1N3N is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db., Ciatto C, Capitani G, Tissot AC, Pecorari F, Pluckthun A, Grutter MG, FEBS Lett. 2003 May 22;543(1-3):11-5. PMID:12753896 Page seeded by OCA on Sat May 3 02:02:50 2008
