This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3v6l
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Crystal Structure of caspase-6 inactivation mutation== | ==Crystal Structure of caspase-6 inactivation mutation== | ||
| - | <StructureSection load='3v6l' size='340' side='right' caption='[[3v6l]], [[Resolution|resolution]] 2.20Å' scene=''> | + | <StructureSection load='3v6l' size='340' side='right'caption='[[3v6l]], [[Resolution|resolution]] 2.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3v6l]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3v6l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V6L FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v6m|3v6m]], [[3nr2|3nr2]], [[3od5|3od5]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v6m|3v6m]], [[3nr2|3nr2]], [[3od5|3od5]]</div></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6 ([ | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v6l OCA], [https://pdbe.org/3v6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v6l RCSB], [https://www.ebi.ac.uk/pdbsum/3v6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v6l ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 22: | ||
==See Also== | ==See Also== | ||
| - | *[[Caspase|Caspase]] | + | *[[Caspase 3D structures|Caspase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
| Line 29: | Line 29: | ||
[[Category: Caspase-6]] | [[Category: Caspase-6]] | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Cao, Q]] | [[Category: Cao, Q]] | ||
[[Category: Li, L F]] | [[Category: Li, L F]] | ||
Revision as of 08:35, 20 July 2022
Crystal Structure of caspase-6 inactivation mutation
| |||||||||||
Categories: Caspase-6 | Human | Large Structures | Cao, Q | Li, L F | Liu, D F | Su, X D | Wang, X J | Apoptotic protease | Caspase domain | Hydrolase
