1n48

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[[Image:1n48.gif|left|200px]]
[[Image:1n48.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1n48 |SIZE=350|CAPTION= <scene name='initialview01'>1n48</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1n48", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=3DR:1&#39;,2&#39;-DIDEOXYRIBOFURANOSE-5&#39;-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= dpo4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2287 Sulfolobus solfataricus])
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-->
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|DOMAIN=
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{{STRUCTURE_1n48| PDB=1n48 | SCENE= }}
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|RELATEDENTRY=[[1jx4|1JX4]], [[1jxl|1JXL]], [[1n56|1N56]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n48 OCA], [http://www.ebi.ac.uk/pdbsum/1n48 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n48 RCSB]</span>
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}}
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'''Y-family DNA polymerase Dpo4 in complex with DNA containing abasic lesion'''
'''Y-family DNA polymerase Dpo4 in complex with DNA containing abasic lesion'''
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[[Category: Woodgate, R.]]
[[Category: Woodgate, R.]]
[[Category: Yang, W.]]
[[Category: Yang, W.]]
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[[Category: dna lesion bypass]]
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[[Category: Dna lesion bypass]]
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[[Category: dna polymerase]]
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[[Category: Dna polymerase]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: y-family]]
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[[Category: Y-family]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:04:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:25:08 2008''
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Revision as of 23:04, 2 May 2008

Image:1n48.gif

Template:STRUCTURE 1n48

Y-family DNA polymerase Dpo4 in complex with DNA containing abasic lesion


Overview

Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) is a DinB homolog that belongs to the recently described Y-family of DNA polymerases, which are best characterized by their low-fidelity synthesis on undamaged DNA templates and propensity to traverse normally replication-blocking lesions. Crystal structures of Dpo4 in ternary complexes with DNA and an incoming nucleotide, either correct or incorrect, have been solved at 1.7 A and 2.1 A resolution, respectively. Despite a conserved active site and a hand-like configuration similar to all known polymerases, Dpo4 makes limited and nonspecific contacts with the replicating base pair, thus relaxing base selection. Dpo4 is also captured in the crystal translocating two template bases to the active site at once, suggesting a possible mechanism for bypassing thymine dimers.

About this Structure

1N48 is a Single protein structure of sequence from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Y-family DNA polymerase in action: a mechanism for error-prone and lesion-bypass replication., Ling H, Boudsocq F, Woodgate R, Yang W, Cell. 2001 Oct 5;107(1):91-102. PMID:11595188 Page seeded by OCA on Sat May 3 02:04:21 2008

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OCA

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