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4ixu

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==Crystal structure of human Arginase-2 complexed with inhibitor 11d: {(5R)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)==
==Crystal structure of human Arginase-2 complexed with inhibitor 11d: {(5R)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)==
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<StructureSection load='4ixu' size='340' side='right' caption='[[4ixu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4ixu' size='340' side='right'caption='[[4ixu]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ixu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IXU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ixu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IXU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=38I:{(5R)-5-AMINO-5-CARBOXY-5-[(3-ENDO)-8-(3,4-DICHLOROBENZYL)-8-AZABICYCLO[3.2.1]OCT-3-YL]PENTYL}(TRIHYDROXY)BORATE(1-)'>38I</scene>, <scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=38I:{(5R)-5-AMINO-5-CARBOXY-5-[(3-ENDO)-8-(3,4-DICHLOROBENZYL)-8-AZABICYCLO[3.2.1]OCT-3-YL]PENTYL}(TRIHYDROXY)BORATE(1-)'>38I</scene>, <scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1d3v|1d3v]], [[1pq3|1pq3]], [[4ixv|4ixv]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ixu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixu OCA], [https://pdbe.org/4ixu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ixu RCSB], [https://www.ebi.ac.uk/pdbsum/4ixu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixu ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ARG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ixu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ixu OCA], [http://pdbe.org/4ixu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ixu RCSB], [http://www.ebi.ac.uk/pdbsum/4ixu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ixu ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
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[https://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Arginase|Arginase]]
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*[[Arginase 3D structures|Arginase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arginase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Andreoli, M]]
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[[Category: Andreoli M]]
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[[Category: Beckett, P]]
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[[Category: Beckett P]]
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[[Category: Cousido-Siah, A]]
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[[Category: Cousido-Siah A]]
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[[Category: Czestkowski, W]]
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[[Category: Czestkowski W]]
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[[Category: Golebiowski, A]]
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[[Category: Golebiowski A]]
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[[Category: Jagdmann, R]]
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[[Category: Jagdmann R]]
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[[Category: Ji, M K]]
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[[Category: Ji MK]]
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[[Category: Mazur, M]]
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[[Category: Mazur M]]
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[[Category: Mitschler, A]]
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[[Category: Mitschler A]]
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[[Category: Olczak, J]]
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[[Category: Olczak J]]
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[[Category: Piotrowska, W]]
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[[Category: Piotrowska W]]
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[[Category: Podjarny, A]]
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[[Category: Podjarny A]]
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[[Category: Ruiz, F X]]
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[[Category: Ruiz FX]]
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[[Category: Ryder, T]]
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[[Category: Ryder T]]
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[[Category: Schroeter, H]]
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[[Category: Schroeter H]]
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[[Category: Whitehouse, D]]
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[[Category: Van Zandt MC]]
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[[Category: Zandt, M C.Van]]
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[[Category: Whitehouse D]]
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[[Category: Alpha/beta fold]]
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[[Category: Arginine metabolism]]
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[[Category: Boronate]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Manganese]]
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[[Category: Metalloenzyme]]
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[[Category: Mitochondrion]]
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Revision as of 21:19, 16 November 2022

Crystal structure of human Arginase-2 complexed with inhibitor 11d: {(5R)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)

PDB ID 4ixu

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