1n4y
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1n4y.gif|left|200px]] | [[Image:1n4y.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1n4y", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1n4y| PDB=1n4y | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''REFINED STRUCTURE OF KISTRIN''' | '''REFINED STRUCTURE OF KISTRIN''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1N4Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry | + | 1N4Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Calloselasma_rhodostoma Calloselasma rhodostoma]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1kst 1kst]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N4Y OCA]. |
==Reference== | ==Reference== | ||
| Line 30: | Line 27: | ||
[[Category: Lazarus, R A.]] | [[Category: Lazarus, R A.]] | ||
[[Category: Wagner, G.]] | [[Category: Wagner, G.]] | ||
| - | [[Category: | + | [[Category: Beta]] |
| - | [[Category: | + | [[Category: Blood coagulation]] |
| - | [[Category: | + | [[Category: Rgd]] |
| - | [[Category: | + | [[Category: Venom]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:06:09 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 23:06, 2 May 2008
REFINED STRUCTURE OF KISTRIN
Overview
The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.
About this Structure
1N4Y is a Single protein structure of sequence from Calloselasma rhodostoma. This structure supersedes the now removed PDB entry 1kst. Full crystallographic information is available from OCA.
Reference
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:1862345 Page seeded by OCA on Sat May 3 02:06:09 2008
