1n4x

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[[Image:1n4x.jpg|left|200px]]
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{{Structure
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|PDB= 1n4x |SIZE=350|CAPTION= <scene name='initialview01'>1n4x</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1n4x", creates the "Structure Box" on the page.
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{{STRUCTURE_1n4x| PDB=1n4x | SCENE= }}
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|RELATEDENTRY=[[1cl7|1cl7]], [[1jp5|1jp5]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n4x OCA], [http://www.ebi.ac.uk/pdbsum/1n4x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n4x RCSB]</span>
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'''Structure of scFv 1696 at acidic pH'''
'''Structure of scFv 1696 at acidic pH'''
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[[Category: Rezacova, P.]]
[[Category: Rezacova, P.]]
[[Category: Sedlacek, J.]]
[[Category: Sedlacek, J.]]
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[[Category: immunoglobulin]]
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[[Category: Immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:06:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:25:29 2008''
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Revision as of 23:06, 2 May 2008

Image:1n4x.jpg

Template:STRUCTURE 1n4x

Structure of scFv 1696 at acidic pH


Overview

The monoclonal antibody 1696, which was raised against the HIV-1 protease, inhibits the catalytic activity of the enzyme from both the HIV-1 and HIV-2 strains. The antibody cross-reacts with peptides containing the N-terminus of the enzyme, which is highly conserved between these strains. The crystal structure of a single-chain Fv fragment of 1696 (scFv-1696) in the non-complexed form, solved at 1.7 A resolution, is compared with the previously reported non-complexed Fab-1696 and antigen-bound scFv-1696 structures. Large conformational changes in the third hypervariable region of the heavy chain and differences in relative orientation of the variable domains are observed between the different structures.

About this Structure

1N4X is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases., Lescar J, Brynda J, Fabry M, Horejsi M, Rezacova P, Sedlacek J, Bentley GA, Acta Crystallogr D Biol Crystallogr. 2003 May;59(Pt 5):955-7. Epub 2003, Apr 25. PMID:12777823 Page seeded by OCA on Sat May 3 02:06:03 2008

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