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Retinoid X receptor

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== Relevance ==
== Relevance ==
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*RXRγ is involved in working memory and despair behavior<ref>PMID:21334601</ref>.<br />
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*RXRγ is involved in working memory and despair behavior<ref>PMID:21334601</ref>. RXR pathway is a positive regulator of myelin debris clearance and has a role in age-related decline in remyelination<ref>PMID:2463675</ref>. <br />
== Structural highlights ==
== Structural highlights ==

Revision as of 07:56, 8 August 2016

Structure of human retinoid X receptor α ligand-binding domain tetramer complex with retinoid (PDB entry 1g5y)

Drag the structure with the mouse to rotate

3D structures of retinoid X receptor

Updated on 08-August-2016

References

  1. ↑ Dawson MI, Xia Z. The retinoid X receptors and their ligands. Biochim Biophys Acta. 2012 Jan;1821(1):21-56. doi: 10.1016/j.bbalip.2011.09.014. , Epub 2011 Oct 1. PMID:22020178 doi:http://dx.doi.org/10.1016/j.bbalip.2011.09.014
  2. ↑ Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ. Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver. Mol Pharmacol. 2004 Mar;65(3):550-7. PMID:14978233 doi:http://dx.doi.org/10.1124/mol.65.3.550
  3. ↑ Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Perez E, de Lera AR, Chambon P, Krezel W. Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice. Biol Psychiatry. 2011 Apr 15;69(8):788-94. doi: 10.1016/j.biopsych.2010.12.017., Epub 2011 Feb 21. PMID:21334601 doi:http://dx.doi.org/10.1016/j.biopsych.2010.12.017
  4. ↑ Nelson RP. Injections of papaverine and regitine into the corpora cavernosa for erectile dysfunction: clinical results in 60 patients. South Med J. 1989 Jan;82(1):26-8. PMID:2463675
  5. ↑ Ireton GC, Black ME, Stoddard BL. The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure. 2003 Aug;11(8):961-72. PMID:12906827

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