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Retinoid X receptor
From Proteopedia
(Difference between revisions)
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**[[2q60]] – RXR LBD – ''Polyandrocarpa misakiensis''<br /> | **[[2q60]] – RXR LBD – ''Polyandrocarpa misakiensis''<br /> | ||
**[[1by4]] – hRXR + DNA<br /> | **[[1by4]] – hRXR + DNA<br /> | ||
| - | **[[1g5y]] - hRXR LBD + retinoid<br /> | + | **[[1g5y]], [[4zhs]] - hRXR LBD + retinoid<br /> |
**[[1dkf]] – mRXR LBD + mRAR LBD – mouse<br /> | **[[1dkf]] – mRXR LBD + mRAR LBD – mouse<br /> | ||
**[[1dsz]] - hRXR LBD + hRAR LBD + DNA<br /> | **[[1dsz]] - hRXR LBD + hRAR LBD + DNA<br /> | ||
| Line 42: | Line 42: | ||
**[[3oap]] - hRXR LBD + 9-''cis'' retinoic acid + coactivator peptide<br /> | **[[3oap]] - hRXR LBD + 9-''cis'' retinoic acid + coactivator peptide<br /> | ||
**[[3uvv]] - hRXR LBD + 9-''cis'' retinoic acid + thyronine + thyroid hormone receptor α<br /> | **[[3uvv]] - hRXR LBD + 9-''cis'' retinoic acid + thyronine + thyroid hormone receptor α<br /> | ||
| + | **[[4zo1]] - hRXR LBD + coactivator peptide + thyroid hormone + thyroid hormone receptor β<br /> | ||
**[[3ozj]] - hRXR LBD + bigelovin + coactivator peptide<br /> | **[[3ozj]] - hRXR LBD + bigelovin + coactivator peptide<br /> | ||
**[[3pcu]] - hRXR LBD + rutamarin + coactivator peptide<br /> | **[[3pcu]] - hRXR LBD + rutamarin + coactivator peptide<br /> | ||
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**[[3kwy]] - hRXR LBD + triphenyltin + coactivator peptide<br /> | **[[3kwy]] - hRXR LBD + triphenyltin + coactivator peptide<br /> | ||
**[[3e94]] - hRXR LBD + tributylin + coactivator peptide<br /> | **[[3e94]] - hRXR LBD + tributylin + coactivator peptide<br /> | ||
| - | **[[2p1t]], [[2p1u]], [[2p1v]] - hRXR LBD + retinoid + coactivator peptide<br /> | + | **[[2p1t]], [[2p1u]], [[2p1v]], [[4rfw]], [[4rmc]], [[4rme]], [[4rmd]] - hRXR LBD + retinoid + coactivator peptide<br /> |
**[[4oc7]] - hRXR LBD + acrylic acid derivative + coactivator peptide<br /> | **[[4oc7]] - hRXR LBD + acrylic acid derivative + coactivator peptide<br /> | ||
| + | **[[5ec9]] - hRXR LBD + benzofuran derivative + coactivator peptide<br /> | ||
**[[4poh]], [[4poj]], [[4pp3]], [[4pp5]] - hRXR LBD + trienoic acid derivative + coactivator peptide<br /> | **[[4poh]], [[4poj]], [[4pp3]], [[4pp5]] - hRXR LBD + trienoic acid derivative + coactivator peptide<br /> | ||
**[[1xls]] - hRXR LBD (mutant) + orphan nuclear receptor NR1I3 + coactivator peptide<br /> | **[[1xls]] - hRXR LBD (mutant) + orphan nuclear receptor NR1I3 + coactivator peptide<br /> | ||
Revision as of 08:48, 8 August 2016
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3D structures of retinoid X receptor
Updated on 08-August-2016
References
- ↑ Dawson MI, Xia Z. The retinoid X receptors and their ligands. Biochim Biophys Acta. 2012 Jan;1821(1):21-56. doi: 10.1016/j.bbalip.2011.09.014. , Epub 2011 Oct 1. PMID:22020178 doi:http://dx.doi.org/10.1016/j.bbalip.2011.09.014
- ↑ Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ. Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver. Mol Pharmacol. 2004 Mar;65(3):550-7. PMID:14978233 doi:http://dx.doi.org/10.1124/mol.65.3.550
- ↑ Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Perez E, de Lera AR, Chambon P, Krezel W. Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice. Biol Psychiatry. 2011 Apr 15;69(8):788-94. doi: 10.1016/j.biopsych.2010.12.017., Epub 2011 Feb 21. PMID:21334601 doi:http://dx.doi.org/10.1016/j.biopsych.2010.12.017
- ↑ Natrajan MS, de la Fuente AG, Crawford AH, Linehan E, Nunez V, Johnson KR, Wu T, Fitzgerald DC, Ricote M, Bielekova B, Franklin RJ. Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain. 2015 Dec;138(Pt 12):3581-97. doi: 10.1093/brain/awv289. Epub 2015 Oct 12. PMID:26463675 doi:http://dx.doi.org/10.1093/brain/awv289
- ↑ Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D. Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. EMBO J. 2000 Jun 1;19(11):2592-601. PMID:10835357 doi:10.1093/emboj/19.11.2592
