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Retinoid X receptor
From Proteopedia
(Difference between revisions)
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**[[3r29]] - hRXR LBD + corepressor peptide SMRT2<br /> | **[[3r29]] - hRXR LBD + corepressor peptide SMRT2<br /> | ||
**[[3r2a]] - hRXR LBD + corepressor peptide SMRT2 + antagonist<br /> | **[[3r2a]] - hRXR LBD + corepressor peptide SMRT2 + antagonist<br /> | ||
| - | **[[3h0a]], [[1fm6]], [[1fm9]], [[1k74]] - hRXR LBD + PPAR-γ + 9-''cis'' retinoic acid + coactivator peptide<br /> | + | **[[3h0a]], [[1fm6]], [[1fm9]], [[1k74]], [[5ji0]] - hRXR LBD + PPAR-γ + 9-''cis'' retinoic acid + coactivator peptide<br /> |
**[[1rdt]] - hRXR LBD + PPAR-γ + coactivator peptide<br /> | **[[1rdt]] - hRXR LBD + PPAR-γ + coactivator peptide<br /> | ||
**[[3dzu]], [[3dzy]], [[3e00]] - hRXR LBD + PPAR-γ + 9-''cis'' retinoic acid + coactivator peptide + DNA<br /> | **[[3dzu]], [[3dzy]], [[3e00]] - hRXR LBD + PPAR-γ + 9-''cis'' retinoic acid + coactivator peptide + DNA<br /> | ||
| - | **[[3oap]] - hRXR LBD + 9-''cis'' retinoic acid + coactivator peptide<br /> | + | **[[3oap]], [[4zhs]] - hRXR LBD + 9-''cis'' retinoic acid + coactivator 2 peptide<br /> |
| + | **[[4zo1]] - hRXR + coactivator 2 peptide + thyroid hormone receptor β<br /> | ||
**[[3uvv]] - hRXR LBD + 9-''cis'' retinoic acid + thyronine + thyroid hormone receptor α<br /> | **[[3uvv]] - hRXR LBD + 9-''cis'' retinoic acid + thyronine + thyroid hormone receptor α<br /> | ||
**[[4zo1]] - hRXR LBD + coactivator peptide + thyroid hormone + thyroid hormone receptor β<br /> | **[[4zo1]] - hRXR LBD + coactivator peptide + thyroid hormone + thyroid hormone receptor β<br /> | ||
**[[3ozj]] - hRXR LBD + bigelovin + coactivator peptide<br /> | **[[3ozj]] - hRXR LBD + bigelovin + coactivator peptide<br /> | ||
**[[3pcu]] - hRXR LBD + rutamarin + coactivator peptide<br /> | **[[3pcu]] - hRXR LBD + rutamarin + coactivator peptide<br /> | ||
| - | **[[2zxz]], [[2zy0]], [[3r5m]], [[1mzn]], [[1mv9]], [[1mvc]], [[4k4j]], [[4k6i]], [[4m8e]], [[4m8h]] - hRXR LBD + agonist + coactivator peptide<br /> | + | **[[2zxz]], [[2zy0]], [[3r5m]], [[1mzn]], [[1mv9]], [[1mvc]], [[4k4j]], [[4k6i]], [[4m8e]], [[4m8h]], [[5lyq]] - hRXR LBD + agonist + coactivator 2 peptide<br /> |
**[[2acl]] - hRXR LBD + agonist + oxysterols receptor α<br /> | **[[2acl]] - hRXR LBD + agonist + oxysterols receptor α<br /> | ||
**[[4ozr]], [[4ozt]] - hRXR LBD + ecdysone receptor <br /> | **[[4ozr]], [[4ozt]] - hRXR LBD + ecdysone receptor <br /> | ||
**[[3fal]] - hRXR LBD + modulator + oxysterols receptor α + 9-''cis'' retinoic acid<br /> | **[[3fal]] - hRXR LBD + modulator + oxysterols receptor α + 9-''cis'' retinoic acid<br /> | ||
| - | **[[4n5g]], [[4n8r]] - hRXR LBD + modulator <br /> | + | **[[4n5g]], [[4n8r]], [[5tbp]] - hRXR LBD + modulator <br /> |
**[[3kwy]] - hRXR LBD + triphenyltin + coactivator peptide<br /> | **[[3kwy]] - hRXR LBD + triphenyltin + coactivator peptide<br /> | ||
**[[3e94]] - hRXR LBD + tributylin + coactivator peptide<br /> | **[[3e94]] - hRXR LBD + tributylin + coactivator peptide<br /> | ||
**[[2p1t]], [[2p1u]], [[2p1v]], [[4rfw]], [[4rmc]], [[4rme]], [[4rmd]] - hRXR LBD + retinoid + coactivator peptide<br /> | **[[2p1t]], [[2p1u]], [[2p1v]], [[4rfw]], [[4rmc]], [[4rme]], [[4rmd]] - hRXR LBD + retinoid + coactivator peptide<br /> | ||
| + | **[[5ec9]] - hRXR LBD + coactivator TIF2 peptide + activator<br /> | ||
**[[4oc7]] - hRXR LBD + acrylic acid derivative + coactivator peptide<br /> | **[[4oc7]] - hRXR LBD + acrylic acid derivative + coactivator peptide<br /> | ||
**[[5ec9]] - hRXR LBD + benzofuran derivative + coactivator peptide<br /> | **[[5ec9]] - hRXR LBD + benzofuran derivative + coactivator peptide<br /> | ||
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**[[1xdk]] - mRXR LBD + mRAR LBD + thyroid receptor associated protein<br /> | **[[1xdk]] - mRXR LBD + mRAR LBD + thyroid receptor associated protein<br /> | ||
**[[1uhl]] - hRXR LBD + oxysterols receptor α + coactivator peptide<br /> | **[[1uhl]] - hRXR LBD + oxysterols receptor α + coactivator peptide<br /> | ||
| - | **[[1h9u]] – hRXR LBD + agonist | + | **[[1h9u]] – hRXR LBD + agonist<br /> |
| + | **[[5hjp]] - hRXR LBD + oxysterols receptor LXR-β + agonist<br /> | ||
*Retinoid X receptor γ | *Retinoid X receptor γ | ||
Revision as of 18:12, 26 September 2017
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3D structures of retinoid X receptor
Updated on 26-September-2017
References
- ↑ Dawson MI, Xia Z. The retinoid X receptors and their ligands. Biochim Biophys Acta. 2012 Jan;1821(1):21-56. doi: 10.1016/j.bbalip.2011.09.014. , Epub 2011 Oct 1. PMID:22020178 doi:http://dx.doi.org/10.1016/j.bbalip.2011.09.014
- ↑ Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ. Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver. Mol Pharmacol. 2004 Mar;65(3):550-7. PMID:14978233 doi:http://dx.doi.org/10.1124/mol.65.3.550
- ↑ Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Perez E, de Lera AR, Chambon P, Krezel W. Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice. Biol Psychiatry. 2011 Apr 15;69(8):788-94. doi: 10.1016/j.biopsych.2010.12.017., Epub 2011 Feb 21. PMID:21334601 doi:http://dx.doi.org/10.1016/j.biopsych.2010.12.017
- ↑ Natrajan MS, de la Fuente AG, Crawford AH, Linehan E, Nunez V, Johnson KR, Wu T, Fitzgerald DC, Ricote M, Bielekova B, Franklin RJ. Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain. 2015 Dec;138(Pt 12):3581-97. doi: 10.1093/brain/awv289. Epub 2015 Oct 12. PMID:26463675 doi:http://dx.doi.org/10.1093/brain/awv289
- ↑ Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D. Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. EMBO J. 2000 Jun 1;19(11):2592-601. PMID:10835357 doi:10.1093/emboj/19.11.2592
