Rho guanine nucleotide exchange factor
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
*'''Rho guanine nucleotide exchange factor 1''' binds to G proteins and stimulate Rho-dependent signals.<br /> | *'''Rho guanine nucleotide exchange factor 1''' binds to G proteins and stimulate Rho-dependent signals.<br /> | ||
| + | *'''Rho guanine nucleotide exchange factor 6''' acts on RAC1.<br /> | ||
== Disease == | == Disease == | ||
| + | Increased GEF activity is involved in cancer cell proliferation by affecting Rho GTPases <ref>PMID:24037532</ref>. | ||
== Relevance == | == Relevance == | ||
Revision as of 07:01, 9 August 2016
| |||||||||||
3D Structures of Rho guanine nucleotide exchange factor
Updated on 09-August-2016
References
- ↑ Cherfils J, Zeghouf M. Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev. 2013 Jan;93(1):269-309. doi: 10.1152/physrev.00003.2012. PMID:23303910 doi:http://dx.doi.org/10.1152/physrev.00003.2012
- ↑ Cook DR, Rossman KL, Der CJ. Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease. Oncogene. 2014 Jul 31;33(31):4021-35. doi: 10.1038/onc.2013.362. Epub 2013 Sep, 16. PMID:24037532 doi:http://dx.doi.org/10.1038/onc.2013.362
