Rhodopsin kinase

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== Disease ==
== Disease ==
Mutations in RK are associated with night blindness<ref>PMID:9020843</ref>.
Mutations in RK are associated with night blindness<ref>PMID:9020843</ref>.
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== Relevance ==
 
== Structural highlights ==
== Structural highlights ==
 +
The active site of RK is located between its small and large lobes and contains the nucleotide and 2 Mg+2 ions<ref>PMID:9020843</ref>. An Asp residue is the catalytic base residue.
</StructureSection>
</StructureSection>

Revision as of 08:07, 9 August 2016

Bovine rhodopsin kinase complex with ATP (stick model), Mg+2 and Cl- ions (PDB code 3c4x)

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3D Structures of rhodopsin kinase

Updated on 09-August-2016

3c4y – bRK – bovine
3t8o – bRK (mutant)
3c4w, 3c4x – bRK + ATP
3c4z, 3c50, 3c51 – bRK + ADP
3qc9 – bRK (mutant) + ADP
4l9i – bRK + paroxetine
4pni – bRK + inhibitor
4wbo – bRK + almexanox

References

  1. ↑ Kuhn H, Wilden U. Deactivation of photoactivated rhodopsin by rhodopsin-kinase and arrestin. J Recept Res. 1987;7(1-4):283-98. PMID:3040978
  2. ↑ Yamamoto S, Sippel KC, Berson EL, Dryja TP. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nat Genet. 1997 Feb;15(2):175-8. PMID:9020843 doi:http://dx.doi.org/10.1038/ng0297-175
  3. ↑ Yamamoto S, Sippel KC, Berson EL, Dryja TP. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nat Genet. 1997 Feb;15(2):175-8. PMID:9020843 doi:http://dx.doi.org/10.1038/ng0297-175

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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