1n7d

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[[Image:1n7d.gif|left|200px]]
[[Image:1n7d.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1n7d |SIZE=350|CAPTION= <scene name='initialview01'>1n7d</scene>, resolution 3.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1n7d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=KEG:12-TUNGSTOPHOSPHATE'>KEG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= LDLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1n7d| PDB=1n7d | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n7d OCA], [http://www.ebi.ac.uk/pdbsum/1n7d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n7d RCSB]</span>
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}}
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'''Extracellular domain of the LDL receptor'''
'''Extracellular domain of the LDL receptor'''
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[[Category: Ichtchenko, K.]]
[[Category: Ichtchenko, K.]]
[[Category: Rudenko, G.]]
[[Category: Rudenko, G.]]
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[[Category: cholesterol metabolism]]
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[[Category: Cholesterol metabolism]]
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[[Category: familial hypercholesterolemia]]
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[[Category: Familial hypercholesterolemia]]
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[[Category: ldl]]
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[[Category: Ldl]]
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[[Category: ldl-receptor]]
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[[Category: Ldl-receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:11:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:26:22 2008''
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Revision as of 23:11, 2 May 2008

Image:1n7d.gif

Template:STRUCTURE 1n7d

Extracellular domain of the LDL receptor


Contents

Overview

The low-density lipoprotein receptor mediates cholesterol homeostasis through endocytosis of lipoproteins. It discharges its ligand in the endosome at pH < 6. In the crystal structure at pH = 5.3, the ligand-binding domain (modules R2 to R7) folds back as an arc over the epidermal growth factor precursor homology domain (the modules A, B, beta propeller, and C). The modules R4 and R5, which are critical for lipoprotein binding, associate with the beta propeller via their calcium-binding loop. We propose a mechanism for lipoprotein release in the endosome whereby the beta propeller functions as an alternate substrate for the ligand-binding domain, binding in a calcium-dependent way and promoting lipoprotein release.

Disease

Known disease associated with this structure: Hypercholesterolemia, familial OMIM:[606945]

About this Structure

1N7D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the LDL receptor extracellular domain at endosomal pH., Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J, Science. 2002 Dec 20;298(5602):2353-8. Epub 2002 Nov 29. PMID:12459547 Page seeded by OCA on Sat May 3 02:11:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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