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5ks2

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'''Unreleased structure'''
 
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The entry 5ks2 is ON HOLD until Paper Publication
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==RAWV_CTD (Helix form) of 16S/23S 2'-O-methyltransferase TlyA==
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<StructureSection load='5ks2' size='340' side='right' caption='[[5ks2]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5ks2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KS2 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5eov|5eov]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ks2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ks2 OCA], [http://pdbe.org/5ks2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ks2 RCSB], [http://www.ebi.ac.uk/pdbsum/5ks2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ks2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TLYA_MYCTU TLYA_MYCTU]] Acts as a host evasion factor, that significantly contributes to the pathogenesis of M.tuberculosis by modulating adaptive immune responses by inhibiting host-protective Th1 and Th17 cytokine responses as well as autophagy (PubMed:25847237). Catalyzes the 2'-O-methylation at nucleotides C1409 in 16S rRNA and C1920 in 23S rRNA (PubMed:16857584, PubMed:20854656). Is likely involved in ribosomal biogenesis (PubMed:21443791). Also exhibits hemolytic activity in vitro, by binding with and oligomerizing into host cell membranes (PubMed:20854656, PubMed:9611795).<ref>PMID:16857584</ref> <ref>PMID:20854656</ref> <ref>PMID:21443791</ref> <ref>PMID:25847237</ref> <ref>PMID:9611795</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Conn, G L]]
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[[Category: Kuiper, E G]]
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[[Category: Antibiotic sensitivity]]
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[[Category: Hemolysin]]
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[[Category: Methyltransferase]]
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[[Category: Ribosome]]
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[[Category: Transferase]]

Revision as of 16:46, 4 January 2017

RAWV_CTD (Helix form) of 16S/23S 2'-O-methyltransferase TlyA

5ks2, resolution 2.18Å

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