5l19

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'''Unreleased structure'''
 
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The entry 5l19 is ON HOLD until Paper Publication
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==Crystal Structure of a human FasL mutant==
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<StructureSection load='5l19' size='340' side='right' caption='[[5l19]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Liu, W., Bonanno, J.B., Almo, S.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5l19]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L19 FirstGlance]. <br>
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Description: Crystal Structure of a human FasL mutant
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4msv|4msv]]</td></tr>
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[[Category: Almo, S.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l19 OCA], [http://pdbe.org/5l19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l19 RCSB], [http://www.ebi.ac.uk/pdbsum/5l19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l19 ProSAT]</span></td></tr>
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[[Category: Bonanno, J.B]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Autoimmune lymphoproliferative syndrome. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/TNFL6_HUMAN TNFL6_HUMAN]] Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.<ref>PMID:17557115</ref> The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition.<ref>PMID:17557115</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Almo, S C]]
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[[Category: Bonanno, J B]]
[[Category: Liu, W]]
[[Category: Liu, W]]
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[[Category: Apoptosis]]
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[[Category: Cd95l]]
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[[Category: Fasl]]
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[[Category: Tnf ligand]]

Revision as of 21:14, 10 September 2016

Crystal Structure of a human FasL mutant

5l19, resolution 2.00Å

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