5l23
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a proline-rich ligand== | |
| - | + | <StructureSection load='5l23' size='340' side='right' caption='[[5l23]], [[Resolution|resolution]] 1.77Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l23]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L23 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L23 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l23 OCA], [http://pdbe.org/5l23 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l23 RCSB], [http://www.ebi.ac.uk/pdbsum/5l23 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l23 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CRK_MOUSE CRK_MOUSE]] The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bhatt, V S]] | ||
| + | [[Category: Cho, J H]] | ||
| + | [[Category: Krieger, I]] | ||
[[Category: Sacchettini, J]] | [[Category: Sacchettini, J]] | ||
| - | [[Category: | + | [[Category: Acetylation]] |
| - | [[Category: | + | [[Category: Amidation]] |
| + | [[Category: C3g]] | ||
| + | [[Category: Crkii]] | ||
| + | [[Category: Protein binding]] | ||
| + | [[Category: Sh3]] | ||
Revision as of 21:14, 10 September 2016
Crystal structure of the complex between the N-terminal SH3 domain of CrkII and a proline-rich ligand
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Categories: Bhatt, V S | Cho, J H | Krieger, I | Sacchettini, J | Acetylation | Amidation | C3g | Crkii | Protein binding | Sh3
