1nb9

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[[Image:1nb9.jpg|left|200px]]
[[Image:1nb9.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1nb9 |SIZE=350|CAPTION= <scene name='initialview01'>1nb9</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_1nb9", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RBF:RIBOFLAVINE'>RBF</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Riboflavin_kinase Riboflavin kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.26 2.7.1.26] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FLJ11149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1nb9| PDB=1nb9 | SCENE= }}
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|RELATEDENTRY=[[1nb0|1NB0]], [[1nbg|1NBG]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nb9 OCA], [http://www.ebi.ac.uk/pdbsum/1nb9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nb9 RCSB]</span>
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}}
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'''Crystal Structure of Riboflavin Kinase'''
'''Crystal Structure of Riboflavin Kinase'''
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[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
[[Category: Zhou, Q.]]
[[Category: Zhou, Q.]]
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[[Category: beta barrel]]
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[[Category: Beta barrel]]
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[[Category: riboflavin]]
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[[Category: Riboflavin]]
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[[Category: riboflavin kinase]]
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[[Category: Riboflavin kinase]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:19:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:27:59 2008''
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Revision as of 23:19, 2 May 2008

Image:1nb9.jpg

Template:STRUCTURE 1nb9

Crystal Structure of Riboflavin Kinase


Overview

Riboflavin kinase (RFK) is an essential enzyme catalyzing the phosphorylation of riboflavin (vitamin B(2)) to form FMN, an obligatory step in vitamin B(2) utilization and flavin cofactor synthesis. The structure of human RFK revealed a six-stranded antiparallel beta barrel core structurally similar to the riboflavin synthase/ferredoxin reductase FAD binding domain fold. The binding site of an intrinsically bound MgADP defines a novel nucleotide binding motif that encompasses a loop, a 3(10) helix, and a reverse turn followed by a short beta strand. This active site loop forms an arch with ATP and riboflavin binding at the opposite side and the phosphoryl transfer appears to occur through the hole underneath the arch. The invariant residues Asn36 and Glu86 are implicated in the catalysis.

About this Structure

1NB9 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch., Karthikeyan S, Zhou Q, Mseeh F, Grishin NV, Osterman AL, Zhang H, Structure. 2003 Mar;11(3):265-73. PMID:12623014 Page seeded by OCA on Sat May 3 02:19:38 2008

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