1nco

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[[Image:1nco.gif|left|200px]]
[[Image:1nco.gif|left|200px]]
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{{Structure
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|PDB= 1nco |SIZE=350|CAPTION= <scene name='initialview01'>1nco</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1nco", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CHR:NEOCARZINOSTATIN-CHROMOPHORE'>CHR</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>
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{{STRUCTURE_1nco| PDB=1nco | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nco OCA], [http://www.ebi.ac.uk/pdbsum/1nco PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nco RCSB]</span>
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'''STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN'''
'''STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN'''
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[[Category: Myers, A G.]]
[[Category: Myers, A G.]]
[[Category: Rees, D C.]]
[[Category: Rees, D C.]]
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[[Category: antibacterial and antitumor protein]]
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[[Category: Antibacterial and antitumor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:22:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:28:32 2008''
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Revision as of 23:22, 2 May 2008

Image:1nco.gif

Template:STRUCTURE 1nco

STRUCTURE OF THE ANTITUMOR PROTEIN-CHROMOPHORE COMPLEX NEOCARZINOSTATIN


Overview

Structures of the protein-chromophore complex and the apoprotein form of neocarzinostatin were determined at 1.8 angstrom resolution. Neocarzinostatin is composed of a labile chromophore with DNA-cleaving activity and a stabilizing protein. The chromophore displays marked nonlinearity of the triple bonds and is bound noncovalently in a pocket formed by the two protein domains. The chromophore pi-face interacts with the phenyl ring edges of Phe52 and Phe78. The amino sugar and carbonate groups of the chromophore are solvent exposed, whereas the epoxide, acetylene groups, and carbon C-12, the site of nucleophilic thiol addition during chromophore activation, are unexposed. The position of the amino group of the chromophore carbohydrate relative to C-12 supports the idea that the amino group plays a role in thiol activation.

About this Structure

1NCO is a Single protein structure of sequence from Streptomyces carzinostaticus. Full crystallographic information is available from OCA.

Reference

Crystal structure of neocarzinostatin, an antitumor protein-chromophore complex., Kim KH, Kwon BM, Myers AG, Rees DC, Science. 1993 Nov 12;262(5136):1042-6. PMID:8235619 Page seeded by OCA on Sat May 3 02:22:27 2008

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