4nwq
From Proteopedia
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==Computationally Designed Two-Component Self-Assembling Tetrahedral Cage, T33-21, Crystallized in Space Group F4132== | ==Computationally Designed Two-Component Self-Assembling Tetrahedral Cage, T33-21, Crystallized in Space Group F4132== | ||
| - | <StructureSection load='4nwq' size='340' side='right' caption='[[4nwq]], [[Resolution|resolution]] 2.80Å' scene=''> | + | <StructureSection load='4nwq' size='340' side='right'caption='[[4nwq]], [[Resolution|resolution]] 2.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4nwq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NWQ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4nwq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae] and [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NWQ FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nwn|4nwn]], [[4nwo|4nwo]], [[4nwp|4nwp]], [[4nwr|4nwr]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nwn|4nwn]], [[4nwo|4nwo]], [[4nwp|4nwp]], [[4nwr|4nwr]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PH0671 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70601 Pyrococcus horikoshii]), PA1966 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwq OCA], [http://pdbe.org/4nwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nwq RCSB], [http://www.ebi.ac.uk/pdbsum/4nwq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwq ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nwq OCA], [http://pdbe.org/4nwq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nwq RCSB], [http://www.ebi.ac.uk/pdbsum/4nwq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nwq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The self-assembly of proteins into highly ordered nanoscale architectures is a hallmark of biological systems. The sophisticated functions of these molecular machines have inspired the development of methods to engineer self-assembling protein nanostructures; however, the design of multi-component protein nanomaterials with high accuracy remains an outstanding challenge. Here we report a computational method for designing protein nanomaterials in which multiple copies of two distinct subunits co-assemble into a specific architecture. We use the method to design five 24-subunit cage-like protein nanomaterials in two distinct symmetric architectures and experimentally demonstrate that their structures are in close agreement with the computational design models. The accuracy of the method and the number and variety of two-component materials that it makes accessible suggest a route to the construction of functional protein nanomaterials tailored to specific applications. | ||
| + | |||
| + | Accurate design of co-assembling multi-component protein nanomaterials.,King NP, Bale JB, Sheffler W, McNamara DE, Gonen S, Gonen T, Yeates TO, Baker D Nature. 2014 Jun 5;510(7503):103-8. doi: 10.1038/nature13404. Epub 2014 May 25. PMID:24870237<ref>PMID:24870237</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 4nwq" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseae]] | ||
| + | [[Category: Pyrococcus horikoshii]] | ||
[[Category: Baker, D]] | [[Category: Baker, D]] | ||
[[Category: Bale, J B]] | [[Category: Bale, J B]] | ||
Revision as of 08:22, 10 April 2019
Computationally Designed Two-Component Self-Assembling Tetrahedral Cage, T33-21, Crystallized in Space Group F4132
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Categories: Large Structures | Pseae | Pyrococcus horikoshii | Baker, D | Bale, J B | King, N P | McNamara, D E | Sheffler, W | Yeates, T O | Computational design | Designed protein cage | Isomerase | Multimerization | Nanomaterial | Nanostructure | Protein binding | Protein engineering | Self-assembling | Tetrahedron | Transferase | Two-component
