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3ro2

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==Structures of the LGN/NuMA complex==
==Structures of the LGN/NuMA complex==
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<StructureSection load='3ro2' size='340' side='right' caption='[[3ro2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='3ro2' size='340' side='right'caption='[[3ro2]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ro2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RO2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ro2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RO2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ro3|3ro3]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ro3|3ro3]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gpsm2, Lgn, Pins ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gpsm2, Lgn, Pins ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ro2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro2 OCA], [http://pdbe.org/3ro2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ro2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ro2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ro2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ro2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ro2 OCA], [https://pdbe.org/3ro2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ro2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ro2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ro2 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/NUMA1_HUMAN NUMA1_HUMAN]] Acute promyelocytic leukemia.
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[[https://www.uniprot.org/uniprot/NUMA1_HUMAN NUMA1_HUMAN]] Acute promyelocytic leukemia.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GPSM2_MOUSE GPSM2_MOUSE]] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. [[http://www.uniprot.org/uniprot/NUMA1_HUMAN NUMA1_HUMAN]] Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.<ref>PMID:19255246</ref>
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[[https://www.uniprot.org/uniprot/GPSM2_MOUSE GPSM2_MOUSE]] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. [[https://www.uniprot.org/uniprot/NUMA1_HUMAN NUMA1_HUMAN]] Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions.<ref>PMID:19255246</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Shang, Y]]
[[Category: Shang, Y]]

Revision as of 10:19, 22 June 2022

Structures of the LGN/NuMA complex

PDB ID 3ro2

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