4mum

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==Crystal structure of mitochondrial 5'(3')-deoxy ribonucleotidase alternative spliced variant==
==Crystal structure of mitochondrial 5'(3')-deoxy ribonucleotidase alternative spliced variant==
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<StructureSection load='4mum' size='340' side='right' caption='[[4mum]], [[Resolution|resolution]] 1.27&Aring;' scene=''>
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<StructureSection load='4mum' size='340' side='right'caption='[[4mum]], [[Resolution|resolution]] 1.27&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mum]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MUM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mum]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MUM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DNT1, NT5C, UMPH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mum OCA], [https://pdbe.org/4mum PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mum RCSB], [https://www.ebi.ac.uk/pdbsum/4mum PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mum ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mum FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mum OCA], [http://pdbe.org/4mum PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mum RCSB], [http://www.ebi.ac.uk/pdbsum/4mum PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mum ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Pachl, P]]
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[[Category: Large Structures]]
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[[Category: Rezacova, P]]
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[[Category: Pachl P]]
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[[Category: 5'-nucleotidase]]
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[[Category: Rezacova P]]
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[[Category: Dephosphorylation]]
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[[Category: Had-like]]
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[[Category: Hydrolase]]
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[[Category: Protein conformation]]
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[[Category: Sequence homology]]
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Revision as of 10:10, 28 December 2022

Crystal structure of mitochondrial 5'(3')-deoxy ribonucleotidase alternative spliced variant

PDB ID 4mum

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