This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Ribonucleotide reductase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | |||
<StructureSection load='1xjg' size='350' side='right' caption='Class II ribonucleotide reductase dimer complex with DATP, UDP (stick models) and Mg+2 ion (green) (PDB entry [[1xjg]])' scene=''> | <StructureSection load='1xjg' size='350' side='right' caption='Class II ribonucleotide reductase dimer complex with DATP, UDP (stick models) and Mg+2 ion (green) (PDB entry [[1xjg]])' scene=''> | ||
== Function == | == Function == | ||
| Line 35: | Line 34: | ||
**[[3hnd]] – hRNR M1 + GDP + TTP<BR /> | **[[3hnd]] – hRNR M1 + GDP + TTP<BR /> | ||
**[[3hne]], [[3hnf]] – hRNR M1 + ATP + TTP<BR /> | **[[3hne]], [[3hnf]] – hRNR M1 + ATP + TTP<BR /> | ||
| - | **[[2wgh]] - hRNR M1 + ATP + Mg<BR /> | + | **[[2wgh]], [[5d1y]] - hRNR M1 + ATP + Mg<BR /> |
| + | **[[4x3v]] - hRNR M1 + inhibitor<br /> | ||
**[[3paw]] - yRNR R1 + ATP<BR /> | **[[3paw]] - yRNR R1 + ATP<BR /> | ||
**[[3k8t]] - yRNR R1 + ADP analog<BR /> | **[[3k8t]] - yRNR R1 + ADP analog<BR /> | ||
| Line 55: | Line 55: | ||
**[[2xof]], [[3n37]], [[3n38]], [[2alx]], [[1piy]], [[1r65]], [[1mxr]], [[1jqc]], [[1jpr]], [[1av8]], [[1xik]], [[1rib]], [[4m1f]] – EcRNR R2 <BR /> | **[[2xof]], [[3n37]], [[3n38]], [[2alx]], [[1piy]], [[1r65]], [[1mxr]], [[1jqc]], [[1jpr]], [[1av8]], [[1xik]], [[1rib]], [[4m1f]] – EcRNR R2 <BR /> | ||
| - | **[[1yfd]], [[1piz]], [[1pj0]], [[1pj1]], [[1pm2]], [[1pim]], [[1piu]], [[1biq]], [[2av8]], [[1pfr]] - EcRNR R2 (mutant) <BR /> | + | **[[1yfd]], [[1piz]], [[1pj0]], [[1pj1]], [[1pm2]], [[1pim]], [[1piu]], [[1biq]], [[2av8]], [[1pfr]] - EcRNR R2 (mutant) + Fe<BR /> |
**[[3hf1]], [[2vux]], [[2uw2]], [[4djn]] – hRNR M2<BR /> | **[[3hf1]], [[2vux]], [[2uw2]], [[4djn]] – hRNR M2<BR /> | ||
**[[3mjo]], [[3dhz]], [[1oqu]], [[1kgn]], [[1kgo]], [[1kgp]] – RNR R2 – ''Corynebacterium ammoniagenes''<BR /> | **[[3mjo]], [[3dhz]], [[1oqu]], [[1kgn]], [[1kgo]], [[1kgp]] – RNR R2 – ''Corynebacterium ammoniagenes''<BR /> | ||
| Line 81: | Line 81: | ||
**[[3n39]], [[3n3a]], [[3n3b]] – EcRNR R2 + NrdI<BR /> | **[[3n39]], [[3n3a]], [[3n3b]] – EcRNR R2 + NrdI<BR /> | ||
**[[1rnr]] – EcRNR R2 (mutant) + dopa<BR /> | **[[1rnr]] – EcRNR R2 (mutant) + dopa<BR /> | ||
| + | **[[5ci4]] – EcRNR R2 (mutant) + FE2O<br /> | ||
| + | **[[5ci3]], [[5ci0]], [[5ci1]], [[5ci2]] – EcRNR R2 (mutant) + fluoro-tyrosine + FE<sub>2</sub>O<br /> | ||
**[[1w69]] – mRNR R2 + acetate<br /> | **[[1w69]] – mRNR R2 + acetate<br /> | ||
| - | **[[4bmo]], [[4bmp]] - BcRNR + | + | **[[4bmo]], [[4bmp]] - BcRNR + NrdI <br /> |
*Ribonucleotide reductase small+large subunit | *Ribonucleotide reductase small+large subunit | ||
| Line 90: | Line 92: | ||
**[[2xak]], [[2xap]], [[2xo4]], [[2xo5]] - EcRNR R1+ R2 peptide<BR /> | **[[2xak]], [[2xap]], [[2xo4]], [[2xo5]] - EcRNR R1+ R2 peptide<BR /> | ||
**[[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR /> | **[[2xav]], [[2xaw]], [[2xax]], [[2xay]], [[2xaz]], [[2x0x]] - EcRNR R1 (mutant) + R2 peptide<BR /> | ||
| - | **[[2bq1]] - StRNR R1+ R2 | + | **[[5cns]], [[5cnt]], [[5cnv]], [[5cnu]] - EcRNR R1 + R2 + 2 nucleotides<br /> |
| + | **[[2bq1]] - StRNR R1+ R2<br /> | ||
| + | **[[5im3]] - RNR + dATP – ''Pseudomonas aeruginosa''<br /> | ||
*'''Class II ribonucleotide reductase''' | *'''Class II ribonucleotide reductase''' | ||
| - | **[[1xjf]] – TmRNR + DATP – ''Thermotoga maritima''<BR /> | + | **[[1xjf]], [[4col]] – TmRNR + DATP – ''Thermotoga maritima''<BR /> |
| - | **[[1xjg]] - TmRNR + | + | **[[4coi]], [[4com]], [[4con]] – TmRNR<br /> |
| + | **[[1xjg]], [[1xjk]], [[1xje]], [[1xjn]], [[4coj]] - TmRNR + 2 nucleotides<BR /> | ||
**[[1xjj]] - TmRNR + GTP<BR /> | **[[1xjj]] - TmRNR + GTP<BR /> | ||
| - | **[[1xjk]] - TmRNR + GTP-ADP<BR /> | ||
**[[1xjm]] - TmRNR + TTP<BR /> | **[[1xjm]] - TmRNR + TTP<BR /> | ||
| - | **[[1xje]] - TmRNR + TTP-GDP<BR /> | ||
| - | **[[1xjn]] - TmRNR + ATP-CDP<br /> | ||
**[[3o0n]] - TmRNR + TTP + Co + Mg + deoxyadenosine + B12<br /> | **[[3o0n]] - TmRNR + TTP + Co + Mg + deoxyadenosine + B12<br /> | ||
**[[3o0o]] - TmRNR + TTP + GDP + Mg + deoxyadenosine + B12<br /> | **[[3o0o]] - TmRNR + TTP + GDP + Mg + deoxyadenosine + B12<br /> | ||
| Line 113: | Line 115: | ||
**[[1h78]], [[1h79]], [[1h7a]], [[1hk8]] – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4<br /> | **[[1h78]], [[1h79]], [[1h7a]], [[1hk8]] – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4<br /> | ||
**[[1h7b]] – T4RNR (mutant) <br /> | **[[1h7b]] – T4RNR (mutant) <br /> | ||
| + | **[[4u3e]] – TmRNR large subunit <br /> | ||
}} | }} | ||
== References == | == References == | ||
Revision as of 09:00, 11 August 2016
| |||||||||||
3D Structures of Ribonucleotide reductase
Updated on 11-August-2016
References
- ↑ Nordlund P, Reichard P. Ribonucleotide reductases. Annu Rev Biochem. 2006;75:681-706. PMID:16756507 doi:http://dx.doi.org/10.1146/annurev.biochem.75.103004.142443
- ↑ Munro JB, Silva JC. Ribonucleotide reductase as a target to control apicomplexan diseases. Curr Issues Mol Biol. 2012;14(1):9-26. Epub 2011 Jul 26. PMID:21791713
- ↑ Larsson KM, Jordan A, Eliasson R, Reichard P, Logan DT, Nordlund P. Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase. Nat Struct Mol Biol. 2004 Nov;11(11):1142-9. Epub 2004 Oct 10. PMID:15475969 doi:http://dx.doi.org/10.1038/nsmb838
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
