1ng3

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[[Image:1ng3.jpg|left|200px]]
[[Image:1ng3.jpg|left|200px]]
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{{Structure
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|PDB= 1ng3 |SIZE=350|CAPTION= <scene name='initialview01'>1ng3</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1ng3", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=AAC:ACETYLAMINO-ACETIC+ACID'>AAC</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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|GENE= GOXB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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|DOMAIN=
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{{STRUCTURE_1ng3| PDB=1ng3 | SCENE= }}
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|RELATEDENTRY=[[1ng4|1NG4]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ng3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ng3 OCA], [http://www.ebi.ac.uk/pdbsum/1ng3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ng3 RCSB]</span>
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'''Complex of ThiO (glycine oxidase) with acetyl-glycine'''
'''Complex of ThiO (glycine oxidase) with acetyl-glycine'''
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[[Category: Park, J.]]
[[Category: Park, J.]]
[[Category: Settembre, E C.]]
[[Category: Settembre, E C.]]
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[[Category: flavoprotein]]
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[[Category: Flavoprotein]]
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[[Category: oxidase]]
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[[Category: Oxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:29:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:29:54 2008''
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Revision as of 23:29, 2 May 2008

Image:1ng3.jpg

Template:STRUCTURE 1ng3

Complex of ThiO (glycine oxidase) with acetyl-glycine


Overview

The thiO gene of Bacillus subtilis encodes an FAD-dependent glycine oxidase. This enzyme is a homotetramer with a monomer molecular mass of 42 kDa. In this paper, we demonstrate that ThiO is required for the biosynthesis of the thiazole moiety of thiamin pyrophosphate and describe the structure of the enzyme with N-acetylglycine bound at the active site. The closest structural relatives of ThiO are sarcosine oxidase and d-amino acid oxidase. The ThiO structure, as well as the observation that N-cyclopropylglycine is a good substrate, supports a hydride transfer mechanism for the enzyme. A mechanistic proposal for the role of ThiO in thiazole biosynthesis is also described.

About this Structure

1NG3 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis., Settembre EC, Dorrestein PC, Park JH, Augustine AM, Begley TP, Ealick SE, Biochemistry. 2003 Mar 18;42(10):2971-81. PMID:12627963 Page seeded by OCA on Sat May 3 02:29:23 2008

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