1ngt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ngt.gif|left|200px]]
[[Image:1ngt.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ngt |SIZE=350|CAPTION= <scene name='initialview01'>1ngt</scene>, resolution 2.04&Aring;
+
The line below this paragraph, containing "STRUCTURE_1ngt", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MTR:(5-METHYL-6-OXO-1,6-DIHYDRO-PYRIDIN-3-YL)-1,2-DIDEOXY-RIBOFURANOSE-5-MONOPHOSPHATE'>MTR</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ngt| PDB=1ngt | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ngt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngt OCA], [http://www.ebi.ac.uk/pdbsum/1ngt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ngt RCSB]</span>
+
-
}}
+
'''The Role of Minor Groove Functional Groups in DNA Hydration'''
'''The Role of Minor Groove Functional Groups in DNA Hydration'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
1NGT is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA].
+
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGT OCA].
==Reference==
==Reference==
The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595562 12595562]
The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12595562 12595562]
-
[[Category: Protein complex]]
 
[[Category: Lan, T.]]
[[Category: Lan, T.]]
[[Category: McLaughlin, L W.]]
[[Category: McLaughlin, L W.]]
[[Category: Williams, L D.]]
[[Category: Williams, L D.]]
[[Category: Woods, K K.]]
[[Category: Woods, K K.]]
-
[[Category: dna conformation]]
+
[[Category: Dna conformation]]
-
[[Category: modified base]]
+
[[Category: Modified base]]
-
[[Category: spine of hydration]]
+
[[Category: Spine of hydration]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:30:52 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:30:11 2008''
+

Revision as of 23:30, 2 May 2008

Image:1ngt.gif

Template:STRUCTURE 1ngt

The Role of Minor Groove Functional Groups in DNA Hydration


Overview

Here we describe the crystal structure of modified [d(CGCGAATTCGCG)]2 refined to 2.04 A. The modification, which affects only the two thymines at the central ApT step, involves isosteric removal of the 2-keto oxygen atoms and substitution of the N1 nitrogen with carbon. The crystal structure reveals the ability of this modified thymine to effectively base pair with adenine in [d(CGCGAAtTCGCG)]2. The structure also suggests that the minor groove 'spine of hydration' is destabilized but essentially intact.

About this Structure

Full crystallographic information is available from OCA.

Reference

The role of minor groove functional groups in DNA hydration., Woods KK, Lan T, McLaughlin LW, Williams LD, Nucleic Acids Res. 2003 Mar 1;31(5):1536-40. PMID:12595562 Page seeded by OCA on Sat May 3 02:30:52 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ngt"
Personal tools