1nih
From Proteopedia
Line 1: | Line 1: | ||
[[Image:1nih.gif|left|200px]] | [[Image:1nih.gif|left|200px]] | ||
- | + | <!-- | |
- | + | The line below this paragraph, containing "STRUCTURE_1nih", creates the "Structure Box" on the page. | |
- | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
- | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
- | + | or leave the SCENE parameter empty for the default display. | |
- | + | --> | |
- | | | + | {{STRUCTURE_1nih| PDB=1nih | SCENE= }} |
- | | | + | |
- | + | ||
- | }} | + | |
'''Structure of deoxy-quaternary haemoglobin with liganded beta subunits''' | '''Structure of deoxy-quaternary haemoglobin with liganded beta subunits''' | ||
Line 27: | Line 24: | ||
[[Category: Liddington, B.]] | [[Category: Liddington, B.]] | ||
[[Category: Luisi, B.]] | [[Category: Luisi, B.]] | ||
- | [[Category: | + | [[Category: Oxygen transport]] |
- | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:34:31 2008'' | |
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + |
Revision as of 23:34, 2 May 2008
Structure of deoxy-quaternary haemoglobin with liganded beta subunits
Overview
We have determined the structure of a T-state haemoglobin in which the haem groups of the beta subunits have carbon monoxide bound, and the alpha subunits have nickel replacing the haem iron and are ligand-free. The structural adjustments on binding ligand in the T state are in the same direction as those associated with the quaternary transition, and a translational shift of the haem is severely restricted. We explain how these observations may account for the low ligand affinity of the beta haem of T-state haemoglobin.
About this Structure
1NIH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of deoxy-quaternary haemoglobin with liganded beta subunits., Luisi B, Liddington B, Fermi G, Shibayama N, J Mol Biol. 1990 Jul 5;214(1):7-14. PMID:2370669 Page seeded by OCA on Sat May 3 02:34:31 2008