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1nlq
From Proteopedia
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'''The crystal structure of Drosophila NLP-core provides insight into pentamer formation and histone binding''' | '''The crystal structure of Drosophila NLP-core provides insight into pentamer formation and histone binding''' | ||
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[[Category: Head, J F.]] | [[Category: Head, J F.]] | ||
[[Category: Namboodiri, V M.H.]] | [[Category: Namboodiri, V M.H.]] | ||
| - | [[Category: | + | [[Category: Chaperone]] |
| - | [[Category: | + | [[Category: Dnlp]] |
| - | [[Category: | + | [[Category: Histone binding]] |
| - | [[Category: | + | [[Category: Nucleoplasmin]] |
| - | [[Category: | + | [[Category: X-ray crystallography]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:40:50 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 23:40, 2 May 2008
The crystal structure of Drosophila NLP-core provides insight into pentamer formation and histone binding
Overview
The nucleoplasmin-like protein from Drosophila (dNLP) functions as a chaperone for core histones and may remodel chromatin in embryos. We now report the crystal structure of a dNLP-core pentamer at 1.5 A resolution. The monomer has an eight-stranded, beta barrel topology that is similar to nucleoplasmin (Np). However, a signature beta hairpin is tucked in along the lateral surface of the dNLP-core pentamer, while it extends outward in the Np-core decamer. Drosophila NLP and Np both assemble histone octamers. This process may require each chaperone to form a decamer, which would create symmetric binding sites for the histones. Conformational differences between dNLP and Np may reflect their different oligomeric states, while a conserved, nonpolar subunit interface may allow conformational plasticity during histone binding.
About this Structure
1NLQ is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
The crystal structure of Drosophila NLP-core provides insight into pentamer formation and histone binding., Namboodiri VM, Dutta S, Akey IV, Head JF, Akey CW, Structure. 2003 Feb;11(2):175-86. PMID:12575937 Page seeded by OCA on Sat May 3 02:40:50 2008
