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3u83

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==Crystal structure of nectin-1==
==Crystal structure of nectin-1==
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<StructureSection load='3u83' size='340' side='right' caption='[[3u83]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='3u83' size='340' side='right'caption='[[3u83]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3u83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U83 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3u83]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U83 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG6:1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE'>PG6</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG6:1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE'>PG6</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3alp|3alp]], [[3u82|3u82]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3alp|3alp]], [[3u82|3u82]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PVRL1, HVEC, PRR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PVRL1, HVEC, PRR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u83 OCA], [http://pdbe.org/3u83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u83 RCSB], [http://www.ebi.ac.uk/pdbsum/3u83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u83 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u83 OCA], [https://pdbe.org/3u83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u83 RCSB], [https://www.ebi.ac.uk/pdbsum/3u83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u83 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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[[https://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Zlotogora-Ogur syndrome;Cleft lip with or without cleft palate. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref>
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[[https://www.uniprot.org/uniprot/PVRL1_HUMAN PVRL1_HUMAN]] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus.<ref>PMID:7721102</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3u83" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3u83" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Fan, Z]]
[[Category: Fan, Z]]
[[Category: Gao, G F]]
[[Category: Gao, G F]]

Revision as of 06:01, 13 July 2022

Crystal structure of nectin-1

PDB ID 3u83

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