4aw2
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/MRCKA_RAT MRCKA_RAT]] Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.<ref>PMID:18854160</ref> <ref>PMID:21457715</ref> <ref>PMID:9418861</ref> | [[http://www.uniprot.org/uniprot/MRCKA_RAT MRCKA_RAT]] Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake.<ref>PMID:18854160</ref> <ref>PMID:21457715</ref> <ref>PMID:9418861</ref> | ||
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| - | ==See Also== | ||
| - | *[[Serine/threonine protein kinase|Serine/threonine protein kinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Azeez, K Abdul]] | [[Category: Azeez, K Abdul]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
| - | [[Category: Delft, F | + | [[Category: Delft, F von]] |
[[Category: Edwards, A]] | [[Category: Edwards, A]] | ||
[[Category: Elkins, J M]] | [[Category: Elkins, J M]] | ||
Revision as of 19:45, 24 January 2018
Crystal structure of CDC42 binding protein kinase alpha (MRCK alpha)
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