4j0u

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==Crystal structure of IFIT5/ISG58==
==Crystal structure of IFIT5/ISG58==
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<StructureSection load='4j0u' size='340' side='right' caption='[[4j0u]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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<StructureSection load='4j0u' size='340' side='right'caption='[[4j0u]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4j0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J0U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4j0u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J0U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J0U FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IFIT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j0u OCA], [https://pdbe.org/4j0u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j0u RCSB], [https://www.ebi.ac.uk/pdbsum/4j0u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j0u ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j0u OCA], [http://pdbe.org/4j0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j0u RCSB], [http://www.ebi.ac.uk/pdbsum/4j0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j0u ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IFIT5_HUMAN IFIT5_HUMAN]] Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.<ref>PMID:23317505</ref> <ref>PMID:23334420</ref>
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[https://www.uniprot.org/uniprot/IFIT5_HUMAN IFIT5_HUMAN] Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.<ref>PMID:23317505</ref> <ref>PMID:23334420</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Cheng, G]]
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[[Category: Large Structures]]
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[[Category: Crowley, C]]
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[[Category: Cheng G]]
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[[Category: Feng, F]]
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[[Category: Crowley C]]
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[[Category: Li, J]]
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[[Category: Feng F]]
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[[Category: Liang, H]]
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[[Category: Li J]]
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[[Category: Liu, Y]]
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[[Category: Liang H]]
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[[Category: Lv, Z]]
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[[Category: Liu Y]]
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[[Category: Wang, Y E]]
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[[Category: Lv Z]]
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[[Category: Yuan, L]]
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[[Category: Wang YE]]
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[[Category: Zeng, S]]
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[[Category: Yuan L]]
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[[Category: Antiviral]]
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[[Category: Zeng S]]
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[[Category: Helix]]
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[[Category: Ifit5 structure]]
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[[Category: Rna binding protein]]
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Revision as of 21:22, 16 November 2022

Crystal structure of IFIT5/ISG58

PDB ID 4j0u

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