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1nsh
From Proteopedia
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[[Image:1nsh.gif|left|200px]] | [[Image:1nsh.gif|left|200px]] | ||
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'''Solution Structure of Rabbit apo-S100A11 (19 models)''' | '''Solution Structure of Rabbit apo-S100A11 (19 models)''' | ||
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[[Category: Shaw, G S.]] | [[Category: Shaw, G S.]] | ||
[[Category: Walsh, M P.]] | [[Category: Walsh, M P.]] | ||
| - | [[Category: | + | [[Category: Calcium-binding protein]] |
| - | [[Category: | + | [[Category: Ef hand]] |
| - | [[Category: | + | [[Category: Helix-loop-helix]] |
| - | [[Category: | + | [[Category: S100a11]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:55:26 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 23:55, 2 May 2008
Solution Structure of Rabbit apo-S100A11 (19 models)
Overview
S100A11 is a homodimeric EF-hand calcium binding protein that undergoes a calcium-induced conformational change and interacts with the phospholipid binding protein annexin I to coordinate membrane association. In this work, the solution structure of apo-S100A11 has been determined by NMR spectroscopy to uncover the details of its calcium-induced structural change. Apo-S100A11 forms a tight globular structure having a near antiparallel orientation of helices III and IV in calcium binding site II. Further, helices I and IV, and I and I', form a more closed arrangement than observed in other apo-S100 proteins. This helix arrangement in apo-S100A11 partially buries residues in helices I (P3, E11, A15), III (V55, R58, M59), and IV (A86, C87, S90) and the linker (A45, F46), which are required for interaction with annexin I in the calcium-bound state. In apo-S100A11, this results in a "masked" binding surface that prevents annexin I binding but is uncovered upon calcium binding.
About this Structure
1NSH is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.
Reference
Unmasking the annexin I interaction from the structure of Apo-S100A11., Dempsey AC, Walsh MP, Shaw GS, Structure. 2003 Jul;11(7):887-97. PMID:12842051 Page seeded by OCA on Sat May 3 02:55:26 2008
