1nst

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[[Image:1nst.gif|left|200px]]
[[Image:1nst.gif|left|200px]]
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{{Structure
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|PDB= 1nst |SIZE=350|CAPTION= <scene name='initialview01'>1nst</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1nst", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3&#39;-5&#39;-DIPHOSPHATE'>A3P</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_1nst| PDB=1nst | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nst OCA], [http://www.ebi.ac.uk/pdbsum/1nst PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nst RCSB]</span>
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}}
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'''THE SULFOTRANSFERASE DOMAIN OF HUMAN HAPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE'''
'''THE SULFOTRANSFERASE DOMAIN OF HUMAN HAPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE'''
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[[Category: Negishi, M.]]
[[Category: Negishi, M.]]
[[Category: Pedersen, L C.]]
[[Category: Pedersen, L C.]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: haparin sulfate]]
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[[Category: Haparin sulfate]]
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[[Category: haparin sulfate biosynthesis]]
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[[Category: Haparin sulfate biosynthesis]]
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[[Category: pap]]
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[[Category: Pap]]
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[[Category: sulfotransferase]]
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[[Category: Sulfotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:56:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:35:02 2008''
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Revision as of 23:56, 2 May 2008

Image:1nst.gif

Template:STRUCTURE 1nst

THE SULFOTRANSFERASE DOMAIN OF HUMAN HAPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE


Overview

Heparan sulfate N-deacetylase/N-sulfotransferase (HSNST) catalyzes the first and obligatory step in the biosynthesis of heparan sulfates and heparin. The crystal structure of the sulfotransferase domain (NST1) of human HSNST-1 has been determined at 2.3-A resolution in a binary complex with 3'-phosphoadenosine 5'-phosphate (PAP). NST1 is approximately spherical with an open cleft, and consists of a single alpha/beta fold with a central five-stranded parallel beta-sheet and a three-stranded anti-parallel beta-sheet bearing an interstrand disulfide bond. The structural regions alpha1, alpha6, beta1, beta7, 5'-phosphosulfate binding loop (between beta1 and alpha1), and a random coil (between beta8 and alpha13) constitute the PAP binding site of NST1. The alpha6 and random coil (between beta2 and alpha2), which form an open cleft near the 5'-phosphate of the PAP molecule, may provide interactions for substrate binding. The conserved residue Lys-614 is in position to form a hydrogen bond with the bridge oxygen of the 5'-phosphate.

About this Structure

1NST is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1., Kakuta Y, Sueyoshi T, Negishi M, Pedersen LC, J Biol Chem. 1999 Apr 16;274(16):10673-6. PMID:10196134 Page seeded by OCA on Sat May 3 02:56:17 2008

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