4dd8

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==ADAM-8 metalloproteinase domain with bound batimastat==
==ADAM-8 metalloproteinase domain with bound batimastat==
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<StructureSection load='4dd8' size='340' side='right' caption='[[4dd8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4dd8' size='340' side='right'caption='[[4dd8]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dd8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DD8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dd8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DD8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE'>BAT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAT:4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE'>BAT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADAM8, MS2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dd8 OCA], [https://pdbe.org/4dd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dd8 RCSB], [https://www.ebi.ac.uk/pdbsum/4dd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dd8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dd8 OCA], [http://pdbe.org/4dd8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4dd8 RCSB], [http://www.ebi.ac.uk/pdbsum/4dd8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4dd8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ADAM8_HUMAN ADAM8_HUMAN]] Possible involvement in extravasation of leukocytes.
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[[https://www.uniprot.org/uniprot/ADAM8_HUMAN ADAM8_HUMAN]] Possible involvement in extravasation of leukocytes.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[A Disintegrin And Metalloproteinase|A Disintegrin And Metalloproteinase]]
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*[[A Disintegrin And Metalloproteinase 3D structures|A Disintegrin And Metalloproteinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Caspers, N]]
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[[Category: Large Structures]]
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[[Category: Chrencik, J E]]
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[[Category: Caspers N]]
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[[Category: Day, J E]]
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[[Category: Chrencik JE]]
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[[Category: Fischer, D H]]
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[[Category: Day JE]]
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[[Category: Hall, T]]
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[[Category: Fischer DH]]
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[[Category: Kiefer, J R]]
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[[Category: Hall T]]
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[[Category: Krahn, J M]]
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[[Category: Kiefer JR]]
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[[Category: Moon, A F]]
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[[Category: Krahn JM]]
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[[Category: Pauley, A M]]
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[[Category: Moon AF]]
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[[Category: Pegg, L E]]
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[[Category: Pauley AM]]
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[[Category: Shieh, H S]]
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[[Category: Pegg LE]]
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[[Category: Tomasselli, A G]]
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[[Category: Shieh HS]]
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[[Category: Williams, J M]]
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[[Category: Tomasselli AG]]
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[[Category: Zack, M D]]
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[[Category: Williams JM]]
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[[Category: Aberrant neural cell signaling]]
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[[Category: Zack MD]]
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[[Category: Allergic asthma]]
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[[Category: Alpha/beta motif]]
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[[Category: Arthritis]]
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[[Category: Batimastat]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Inflammation]]
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[[Category: Metalloproteinase]]
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[[Category: Tumorigenesis]]
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Revision as of 08:12, 21 September 2022

ADAM-8 metalloproteinase domain with bound batimastat

PDB ID 4dd8

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