1ntb

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[[Image:1ntb.gif|left|200px]]
[[Image:1ntb.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ntb |SIZE=350|CAPTION= <scene name='initialview01'>1ntb</scene>, resolution 2.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1ntb", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SRY:STREPTOMYCIN'>SRY</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1ntb| PDB=1ntb | SCENE= }}
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|RELATEDENTRY=[[1nta|1NTA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ntb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ntb OCA], [http://www.ebi.ac.uk/pdbsum/1ntb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ntb RCSB]</span>
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}}
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'''2.9 A crystal structure of Streptomycin RNA-aptamer complex'''
'''2.9 A crystal structure of Streptomycin RNA-aptamer complex'''
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==About this Structure==
==About this Structure==
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1NTB is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTB OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NTB OCA].
==Reference==
==Reference==
Encapsulating streptomycin within a small 40-mer RNA., Tereshko V, Skripkin E, Patel DJ, Chem Biol. 2003 Feb;10(2):175-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12618190 12618190]
Encapsulating streptomycin within a small 40-mer RNA., Tereshko V, Skripkin E, Patel DJ, Chem Biol. 2003 Feb;10(2):175-87. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12618190 12618190]
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[[Category: Protein complex]]
 
[[Category: Patel, D J.]]
[[Category: Patel, D J.]]
[[Category: Skripkin, E.]]
[[Category: Skripkin, E.]]
[[Category: Tereshko, V.]]
[[Category: Tereshko, V.]]
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[[Category: magnesium form]]
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[[Category: Magnesium form]]
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[[Category: streptomycin rna-aptamer]]
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[[Category: Streptomycin rna-aptamer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:57:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:35:12 2008''
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Revision as of 23:57, 2 May 2008

Template:STRUCTURE 1ntb

2.9 A crystal structure of Streptomycin RNA-aptamer complex


Overview

We describe a 2.9 A X-ray structure of a complex between the aminocyclitol antibiotic streptomycin and an in vitro selected RNA aptamer, solved using the anomalous diffraction properties of Ba cations. The RNA aptamer, which contains two asymmetric internal loops, adopts a distinct cation-stabilized fold involving a series of S-shaped backbone turns anchored by canonical and noncanonical pairs and triples. The streptomycin streptose ring is encapsulated by stacked arrays of bases from both loops at the elbow of the L-shaped RNA architecture. Specificity is defined by direct hydrogen bonds between all streptose functional groups and base edges that line the inner walls of the cylindrical binding pocket. By contrast, the majority of intermolecular interactions involve contacts to backbone phosphates in the published structure of streptomycin bound to the 16S rRNA.

About this Structure

Full crystallographic information is available from OCA.

Reference

Encapsulating streptomycin within a small 40-mer RNA., Tereshko V, Skripkin E, Patel DJ, Chem Biol. 2003 Feb;10(2):175-87. PMID:12618190 Page seeded by OCA on Sat May 3 02:57:16 2008

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