1nte

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1nte.jpg|left|200px]]
[[Image:1nte.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1nte |SIZE=350|CAPTION= <scene name='initialview01'>1nte</scene>, resolution 1.24&Aring;
+
The line below this paragraph, containing "STRUCTURE_1nte", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=O:OXYGEN+ATOM'>O</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= SDCBP OR MDA9 OR SYCL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1nte| PDB=1nte | SCENE= }}
-
|RELATEDENTRY=[[1n99|1N99]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nte FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nte OCA], [http://www.ebi.ac.uk/pdbsum/1nte PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nte RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE ANALYSIS OF THE SECOND PDZ DOMAIN OF SYNTENIN'''
'''CRYSTAL STRUCTURE ANALYSIS OF THE SECOND PDZ DOMAIN OF SYNTENIN'''
Line 30: Line 27:
[[Category: Devedjiev, Y.]]
[[Category: Devedjiev, Y.]]
[[Category: Kang, B S.]]
[[Category: Kang, B S.]]
-
[[Category: pdz recognition]]
+
[[Category: Pdz recognition]]
-
[[Category: syntenin]]
+
[[Category: Syntenin]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 02:57:27 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:35:15 2008''
+

Revision as of 23:57, 2 May 2008

Image:1nte.jpg

Template:STRUCTURE 1nte

CRYSTAL STRUCTURE ANALYSIS OF THE SECOND PDZ DOMAIN OF SYNTENIN


Overview

Crystal structures of the PDZ2 domain of the scaffolding protein syntenin, both unbound and in complexes with peptides derived from C termini of IL5 receptor (alpha chain) and syndecan, reveal the molecular roots of syntenin's degenerate specificity. Three distinct binding sites (S(0), S(-1), and S(-2)), with affinities for hydrophobic side chains, function in a combinatorial way: S(-1) and S(-2) act together to bind syndecan, while S(0) and S(-1) are involved in the binding of IL5Ralpha. Neither mode of interaction is consistent with the prior classification scheme, which defined the IL5Ralpha interaction as class I (-S/T-X-phi) and the syndecan interaction as class II (-phi-X-phi). These results, in conjunction with other emerging structural data on PDZ domains, call for a revision of their classification and of the existing model of their mechanism.

About this Structure

1NTE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular roots of degenerate specificity in syntenin's PDZ2 domain: reassessment of the PDZ recognition paradigm., Kang BS, Cooper DR, Devedjiev Y, Derewenda U, Derewenda ZS, Structure. 2003 Jul;11(7):845-53. PMID:12842047 Page seeded by OCA on Sat May 3 02:57:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1nte"
Personal tools