1nw2

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[[Image:1nw2.jpg|left|200px]]
[[Image:1nw2.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1nw2 |SIZE=350|CAPTION= <scene name='initialview01'>1nw2</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1nw2", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1nw2| PDB=1nw2 | SCENE= }}
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|RELATEDENTRY=[[1quw|1QUW]], [[2trx|2TRX]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nw2 OCA], [http://www.ebi.ac.uk/pdbsum/1nw2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nw2 RCSB]</span>
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}}
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'''The crystal structure of the mutant R82E of Thioredoxin from Alicyclobacillus acidocaldarius'''
'''The crystal structure of the mutant R82E of Thioredoxin from Alicyclobacillus acidocaldarius'''
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[[Category: Saviano, M.]]
[[Category: Saviano, M.]]
[[Category: Simone, G De.]]
[[Category: Simone, G De.]]
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[[Category: thermostability]]
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[[Category: Thermostability]]
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[[Category: thioredoxin]]
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[[Category: Thioredoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:02:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:36:23 2008''
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Revision as of 00:02, 3 May 2008

Image:1nw2.jpg

Template:STRUCTURE 1nw2

The crystal structure of the mutant R82E of Thioredoxin from Alicyclobacillus acidocaldarius


Overview

We report a crystallographic and computational analysis of two mutant forms of the Alicyclobacillus acidocaldarius thioredoxin (BacTrx) done in order to evaluate the contribution of two specific amino acids to the thermostability of BacTrx. Our results suggest that the thermostability of BacTrx may be modulated by mutations affecting the overall electrostatic energy of the protein.

About this Structure

1NW2 is a Single protein structure of sequence from Alicyclobacillus acidocaldarius. Full crystallographic information is available from OCA.

Reference

An integrated structural and computational study of the thermostability of two thioredoxin mutants from Alicyclobacillus acidocaldarius., Bartolucci S, De Simone G, Galdiero S, Improta R, Menchise V, Pedone C, Pedone E, Saviano M, J Bacteriol. 2003 Jul;185(14):4285-9. PMID:12837806 Page seeded by OCA on Sat May 3 03:02:49 2008

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