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1nyd
From Proteopedia
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[[Image:1nyd.gif|left|200px]] | [[Image:1nyd.gif|left|200px]] | ||
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'''Solution structure of DNA quadruplex GCGGTGGAT''' | '''Solution structure of DNA quadruplex GCGGTGGAT''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NYD OCA]. | |
==Reference== | ==Reference== | ||
Association of DNA quadruplexes through G:C:G:C tetrads. Solution structure of d(GCGGTGGAT)., Webba da Silva M, Biochemistry. 2003 Dec 16;42(49):14356-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14661946 14661946] | Association of DNA quadruplexes through G:C:G:C tetrads. Solution structure of d(GCGGTGGAT)., Webba da Silva M, Biochemistry. 2003 Dec 16;42(49):14356-65. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14661946 14661946] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Silva, M Webba da.]] | [[Category: Silva, M Webba da.]] | ||
| - | [[Category: | + | [[Category: Double chain reversal,dna]] |
| - | [[Category: | + | [[Category: Molecular propeller topology]] |
| - | [[Category: | + | [[Category: Parallel quadruplex]] |
| - | [[Category: | + | [[Category: Quadruplex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:08:04 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 00:08, 3 May 2008
Solution structure of DNA quadruplex GCGGTGGAT
Overview
The structure formed by the DNA sequence d(GCGGTGGAT) in a 100 mM Na(+) solution has been determined using molecular dynamics calculations constrained by distance and dihedral restraints derived from NMR experiments performed at isotopic natural abundance. The sequence folds into a dimer of dimers. Each symmetry-related half contains two parallel stranded G:G:G:G tetrads flanked by an A:A mismatch and by four-stranded G:C:G:C tetrads. Each of the two juxtaposed G:C:G:C tetrads is composed of alternating antiparallel strands from the two halves of the dimer. For each single strand, a thymine intersperses a double chain reversal connecting the juxtaposed G:G:G:G tetrads. This architecture has potential implications in genetic recombination. It suggests a pathway for oligomerization involving association of quadruplex entities through GpC steps.
About this Structure
Full crystallographic information is available from OCA.
Reference
Association of DNA quadruplexes through G:C:G:C tetrads. Solution structure of d(GCGGTGGAT)., Webba da Silva M, Biochemistry. 2003 Dec 16;42(49):14356-65. PMID:14661946 Page seeded by OCA on Sat May 3 03:08:04 2008
