1nzv

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[[Image:1nzv.jpg|left|200px]]
[[Image:1nzv.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1nzv |SIZE=350|CAPTION= <scene name='initialview01'>1nzv</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1nzv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= V-SRC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11886 Rous sarcoma virus])
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-->
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|DOMAIN=
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{{STRUCTURE_1nzv| PDB=1nzv | SCENE= }}
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|RELATEDENTRY=[[1iso|1ISO]], [[1kc2|1KC2]], [[1nzl|1NZL]], [[1sps|1SPS]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nzv OCA], [http://www.ebi.ac.uk/pdbsum/1nzv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nzv RCSB]</span>
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}}
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'''Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYIpYVPA'''
'''Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYIpYVPA'''
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[[Category: Lubman, O Y.]]
[[Category: Lubman, O Y.]]
[[Category: Waksman, G.]]
[[Category: Waksman, G.]]
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[[Category: phosphotyrosine]]
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[[Category: Phosphotyrosine]]
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[[Category: sh2 domain]]
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[[Category: Sh2 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 03:11:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:37:51 2008''
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Revision as of 00:11, 3 May 2008

Image:1nzv.jpg

Template:STRUCTURE 1nzv

Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYIpYVPA


Overview

Recruitment of the Src kinase to the activated form of the platelet-derived growth factor (PDGF) receptor involves recognition of a unique sequence motif in the juxtamembrane region of the receptor by the Src homology 2 (SH2) domain of the enzyme. This motif contains two phosphotyrosine residues separated by one residue (sequence pYIpYV where pY indicates a phosphotyrosine). Here, we provide the thermodynamic and structural basis for the binding of this motif by the Src SH2 domain. We show that the second phosphorylation event increases the free energy window for specific interaction and that the physiological target is exquisitely designed for the task of recruiting specifically an SH2 domain which otherwise demonstrates very little intrinsic ability to discriminate sequences C-terminal to the first phosphorylation event. Surprisingly, we show that water plays a role in the recognition process.

About this Structure

1NZV is a Single protein structure of sequence from Rous sarcoma virus. Full crystallographic information is available from OCA.

Reference

Structural and thermodynamic basis for the interaction of the Src SH2 domain with the activated form of the PDGF beta-receptor., Lubman OY, Waksman G, J Mol Biol. 2003 May 2;328(3):655-68. PMID:12706723 Page seeded by OCA on Sat May 3 03:11:34 2008

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OCA

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